利用碳-碳键裂解/芳基化反应构建对映体纯紫杉烷类化合物和天然产物样骨架。
Construction of Enantiopure Taxoid and Natural Product-like Scaffolds Using a C-C Bond Cleavage/Arylation Reaction.
作者信息
Weber Manuel, Owens Kyle, Masarwa Ahmad, Sarpong Richmond
机构信息
Department of Chemistry, University of California-Berkeley , Berkeley, California 94720, United States.
出版信息
Org Lett. 2015 Nov 6;17(21):5432-5. doi: 10.1021/acs.orglett.5b02797. Epub 2015 Oct 20.
PMID:26485318
Abstract
An approach to construct enantiopure complex natural product-like frameworks, including the first reported synthesis of a C17 oxygenated taxoid scaffold, is presented. A palladium-catalyzed C-C activation/cross-coupling is utilized to access these structures in a short sequence from (+)-carvone; the scope of this reaction is explored.
摘要
本文介绍了一种构建对映体纯的类复杂天然产物骨架的方法，包括首次报道的C17氧化紫杉烷骨架的合成。利用钯催化的C-C活化/交叉偶联反应，以(+)-香芹酮为原料，通过简短的步骤合成这些结构，并对该反应的适用范围进行了探索。
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