Jenhani F, Bardi R, Gorgi Y, Ayed K, Chammaki S, Boukhris R
Laboratoire d'Imunologie, Faculté de Médecine de Tunis.
Ann Biol Clin (Paris). 1989;47(1):23-8.
There is no doubt that the autoimmune process in human disease depends on genetic factors. Varying associations were noticed between HLA DR and autoimmune disorders. The frequency of HLA-A-B and DR antigens as well as the Bf and C4 allotypes have been investigated in insulinodependant diabetes mellitus (IDDM) and compared to that of healthy controls in Tunisian population. An increase of A30, DR3, DR4, BfF1, C4AQ0 and C4BQ0 and decrease of B40, DR2, DR5 and DR6 were found in diabetes when compared to the value observation controls. The strongest association was noticed with HLA, DR3 and DR4. The prospective role of DR2 and DR5 antigens were also confirmed. Examination of HLA, Bf and C4 alleles. Two supratypes associated with IDDM have been observed among the Tunisian patients.
毫无疑问，人类疾病中的自身免疫过程取决于遗传因素。人们注意到HLA DR与自身免疫性疾病之间存在不同的关联。在突尼斯人群中，对胰岛素依赖型糖尿病（IDDM）患者的HLA - A - B和DR抗原以及Bf和C4同种异型的频率进行了研究，并与健康对照者进行了比较。与观察对照组的值相比，糖尿病患者中A30、DR3、DR4、BfF1、C4AQ0和C4BQ0增加，而B40、DR2、DR5和DR6减少。与HLA、DR3和DR4的关联最为显著。DR2和DR5抗原的前瞻性作用也得到了证实。对HLA、Bf和C4等位基因进行检测。在突尼斯患者中观察到两种与IDDM相关的超型。
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