[1例术前化疗后直肠癌伴多发肝肺转移的根治性切除术病例]

[A Case of Radical Resection of Rectal Cancer with Multiple Liver and Lung Metastases after Preoperative Chemotherapy].

作者信息

Yamashita Shinya, Shimizu Yosuke, Tominaga Harumi, Kimura Yuri, Odagiri Kazuki, Kurokawa Tomoaki, Yamaguchi Megumi, Takahashi Gen, Sawada Genta, Moon JeongHo, Inoue Masashi, Irei Toshimitsu, Nakahira Shin, Hatanaka Nobutaka

机构信息

Dept. of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center.

出版信息

Gan To Kagaku Ryoho. 2015 Oct;42(10):1274-6.

PMID:26489570

Abstract

We report a case of radical resection of rectal cancer with multiple liver and lung metastases after preoperative chemotherapy. A 54-year-old woman presented with abdominal pain and loss of body weight due to rectal cancer with multiple liver and lung metastases. Therefore, the patient received 14 courses of bevacizumab+mFOLFOX6, and 7 courses of panitumumab+FOLFIRI. After the chemotherapy, the size of the distant metastases reduced by 62% on computed tomography, according to RECIST. Due to the reduction in size, a conversion surgery was attempted. First, an abdominal operation with laparoscopy was performed, and 2 months later an operation to resect the lung metastases via thoracoscopy was performed. Currently, 3 months after surgery, the patient is alive, without recurrence.

摘要

我们报告了一例术前化疗后出现多发肝肺转移的直肠癌根治性切除术病例。一名54岁女性因直肠癌伴多发肝肺转移出现腹痛和体重减轻。因此，该患者接受了14个疗程的贝伐单抗+mFOLFOX6以及7个疗程的帕尼单抗+FOLFIRI化疗。化疗后，根据实体瘤疗效评价标准（RECIST），计算机断层扫描显示远处转移灶大小缩小了62%。由于转移灶大小缩小，尝试进行了转化手术。首先进行了腹腔镜腹部手术，2个月后通过胸腔镜进行了肺转移灶切除术。目前，术后3个月，患者存活，无复发。