Silici S, Doğan Z, Sahin H, Atayoğlu T, Yakan B
Agriculture Faculty, Department of Agricultural Biotechnology, Agriculture Research Unit, Erciyes University, 38039, Kayseri, Turkey.
Science Faculty, Department of Biology, Erciyes University, Kayseri, Turkey.
Environ Sci Pollut Res Int. 2016 Feb;23(4):3300-9. doi: 10.1007/s11356-015-5534-z. Epub 2015 Oct 21.
The aim of the study is to evaluate the acute biochemical and histological changes in rat kidneys after treatment with grayanotoxin (GTX) of rhododendron honey (RH). A total of 60 Sprague-Dawley female rats were divided into five groups of 12 rats each, one being a control group (group 1) and group 2 was treated with 0.015 mg/kg/bw of GTX standard preparation via intraperitoneal injection. Groups 3, 4, and 5 were given RH at doses of 0.1, 0.5, and 2.5 g/kg/bw, respectively, via oral gavage. Compared to the control group, significant increases were observed in glucose, blood urea nitrogen (BUN), and creatinine levels of the GTX-injected groups after 1 h. However, in low dose RH group, such an increase was not observed and had a normal appearance histologically. Therefore, low dose (1 g/kg/bw) of RH produces no acute adverse effects on renal functions of rats.
本研究的目的是评估用杜鹃花蜂蜜（RH）中的灰藜毒素（GTX）处理后大鼠肾脏的急性生化和组织学变化。总共60只Sprague-Dawley雌性大鼠被分为五组，每组12只，一组为对照组（第1组），第2组通过腹腔注射给予0.015 mg/kg体重的GTX标准制剂。第3、4和5组分别通过灌胃给予剂量为0.1、0.5和2.5 g/kg体重的RH。与对照组相比，注射GTX的组在1小时后血糖、血尿素氮（BUN）和肌酐水平显著升高。然而，在低剂量RH组中，未观察到这种升高，并且组织学外观正常。因此，低剂量（1 g/kg体重）的RH对大鼠肾功能没有产生急性不良影响。
