Beghi Massimiliano, Negrini Paola Beffa, Perin Cecilia, Peroni Federica, Magaudda Adriana, Cerri Cesare, Cornaggia Cesare Maria
Department of Surgery and Translational Medicine, University of Milano-Bicocca, Milan, Italy ; Department of Mental Health, "Guido Salvini" Hospital, Garbagnate Milanese, Milan, Italy.
Department of Surgery and Translational Medicine, University of Milano-Bicocca, Milan, Italy.
Neuropsychiatr Dis Treat. 2015 Sep 30;11:2519-27. doi: 10.2147/NDT.S82079. eCollection 2015.
In Diagnostic and Statistical Manual of Mental Disorders, fifth edition, psychogenic non-epileptic seizures (PNES) do not have a unique classification as they can be found within different categories: conversion, dissociative, and somatization disorders. The ICD-10, instead, considers PNES within dissociative disorders, merging the dissociative disorders and conversion disorders, although the underlying defense mechanisms are different. The literature data show that PNES are associated with cluster B (mainly borderline) personality disorders and/or to people with depressive or anxiety disorders. Defense mechanisms in patients with PNES with a prevalence of anxious/depressive symptoms are of "neurotic" type; their goal is to lead to a "split", either vertical (dissociation) or horizontal (repression). The majority of patients with this type of PNES have alexithymia traits, meaning that they had difficulties in feeling or perceiving emotions. In subjects where PNES are associated with a borderline personality, in which the symbolic function is lost, the defense mechanisms are of a more archaic nature (denial). PNES with different underlying defense mechanisms have different prognoses (despite similar severity of PNES) and need usually a different treatment (pharmacological or psychological). Thus, it appears superfluous to talk about psychiatric comorbidity, since PNES are a different symptomatic expression of specific psychiatric disorders.
在《精神疾病诊断与统计手册》第五版中,心因性非癫痫性发作(PNES)没有独特的分类,因为它们可出现在不同类别中:转换障碍、分离障碍和躯体化障碍。相反,国际疾病分类第十版(ICD - 10)将PNES归为分离障碍,合并了分离障碍和转换障碍,尽管其潜在的防御机制不同。文献数据表明,PNES与B类人格障碍(主要是边缘型人格障碍)和/或患有抑郁或焦虑障碍的人有关。伴有焦虑/抑郁症状的PNES患者的防御机制属于“神经症性”类型;其目的是导致“分裂”,无论是纵向(分离)还是横向(压抑)。这类PNES的大多数患者具有述情障碍特征,即他们在感受或感知情绪方面存在困难。在PNES与边缘型人格相关的个体中,其象征功能丧失,防御机制具有更原始的性质(否认)。具有不同潜在防御机制的PNES有不同的预后(尽管PNES的严重程度相似),通常需要不同的治疗(药物治疗或心理治疗)。因此,谈论精神科共病似乎是多余的,因为PNES是特定精神疾病的不同症状表现。