Komarowska Marta Diana, Hermanowicz Adam, Czyzewska Urszula, Milewski Robert, Matuszczak Ewa, Miltyk Wojciech, Debek Wojciech
Department of Pediatric Surgery, Medical University of Bialystok, Ulica Waszyngtona 17, 15-274 Bialystok, Poland.
Department of Pharmaceutical Analysis, Medical University of Bialystok, Ulica Adama Mickiewicza 2D, 15-222 Bialystok, Poland.
Int J Endocrinol. 2015;2015:973154. doi: 10.1155/2015/973154. Epub 2015 Sep 28.
Cryptorchidism is the most common congenital birth defect in boys and affects about 2-4% full-term male neonates. Its etiology is multifactorial. Purpose. To evaluate the serum bisphenol A (BPA) levels in boys with cryptorchidism and healthy boys and to assess the risk of environmental exposure to BPA using the authors' questionnaire. The data were acquired from a study on boys with cryptorchidism (n = 98) and a control group (n = 57). Prior to surgery, all patients had BPA serum levels evaluated. The size, position, rigidity of the testis, and abnormality of the epididymis of the undescended testis were assessed. Parents also completed a questionnaire on the risks of exposure to BPA in everyday life. Results. The testes in both groups were similar in size. The turgor of the undescended testis in the group of boys with cryptorchidism was decreased. Free serum BPA level in cryptorchid boys and in the control group was not statistically significant (p > 0.05). The conjugated serum BPA level in cryptorchid boys and in the control group was statistically significant (p ≤ 0.05). Total serum BPA level in cryptorchid boys and in the control group was statistically significant (p < 0.05). Serum total BPA level was related with a positive answer about problems with conception (p < 0.02). Conclusion. Our study indicated that high serum BPA was associated with cryptorchidism.
隐睾症是男性最常见的先天性出生缺陷，影响约2-4%的足月男婴。其病因是多因素的。目的：评估隐睾症男孩和健康男孩的血清双酚A（BPA）水平，并使用作者的问卷评估环境暴露于BPA的风险。数据来自一项对隐睾症男孩（n = 98）和对照组（n = 57）的研究。在手术前，所有患者都进行了BPA血清水平评估。评估了未降睾丸的大小、位置、硬度以及附睾的异常情况。家长还填写了一份关于日常生活中接触BPA风险的问卷。结果：两组睾丸大小相似。隐睾症男孩组中未降睾丸的弹性降低。隐睾症男孩和对照组的游离血清BPA水平无统计学意义（p > 0.05）。隐睾症男孩和对照组的结合血清BPA水平有统计学意义（p ≤ 0.05）。隐睾症男孩和对照组的血清总BPA水平有统计学意义（p < 0.05）。血清总BPA水平与受孕问题的肯定回答相关（p < 0.02）。结论：我们的研究表明，高血清BPA与隐睾症有关。
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