Dean Derek J, Orr Joseph M, Newberry Raeana E, Mittal Vijay A
University of Colorado Boulder, Department of Psychology and Neuroscience, United States; University of Colorado Boulder, Center for Neuroscience, United States.
Texas A&M University, Department of Psychology, United States.
Schizophr Res. 2016 Jan;170(1):137-42. doi: 10.1016/j.schres.2015.10.017. Epub 2015 Oct 20.
A body of work focusing on brain connectivity, language dominance, and motor laterality research suggests that reduced hemispheric asymmetry is a core feature in schizophrenia. However, there is little consensus about whether reduced dominance is present in those at ultrahigh risk (UHR) for psychosis.
A total of 94 demonstrated right-handed neuroleptic free participants (38 UHR and 56 matched healthy controls) were assessed with structured clinical interviews and completed an innovative handwriting task using a digital tablet computer. A laterality quotient (LQ) was calculated using kinematic variables from the participant's left and right hands. A subset of the sample (26 UHR and 29 controls) returned after 12-months to complete clinical interviews in order to examine relationships between handwriting laterality and progression of psychosis risk symptoms.
The UHR group showed decreased dextrality compared to healthy controls. At the 12-month follow-up, decreased dextrality accounted for 8% of the variance in worsened positive symptoms within the UHR group.
The current results suggest that disrupted cerebral dominance is also present in the ultrahigh risk period and that decreased dextrality may serve as a novel biomarker for the progression of psychosis risk.
一系列专注于脑连接性、语言优势和运动偏侧性研究的工作表明,半球不对称性降低是精神分裂症的一个核心特征。然而,对于精神病超高风险(UHR)人群是否存在优势降低,目前几乎没有共识。
共有94名已证实为右利手且未服用抗精神病药物的参与者(38名UHR者和56名匹配的健康对照者)接受了结构化临床访谈,并使用数字平板电脑完成了一项创新的笔迹任务。利用参与者左手和右手的运动学变量计算偏侧商(LQ)。样本中的一部分(26名UHR者和29名对照者)在12个月后返回完成临床访谈,以检查笔迹偏侧性与精神病风险症状进展之间的关系。
与健康对照相比,UHR组的右利手程度降低。在12个月的随访中,右利手程度降低占UHR组阳性症状恶化方差的8%。
当前结果表明,在超高风险期也存在大脑优势破坏,右利手程度降低可能作为精神病风险进展的一种新的生物标志物。