登革热流行病学与发病机制：透过历史之镜展望未来图景。
Dengue epidemiology and pathogenesis: images of the future viewed through a mirror of the past.
作者信息
Islam Rashedul, Salahuddin Mohammed, Ayubi Md Salahuddin, Hossain Tahmina, Majumder Apurba, Taylor-Robinson Andrew W, Mahmud-Al-Rafat Abdullah
机构信息
Bio-Resources Technology and Industrial Biotechnology Laboratory, Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Dhaka, 1342, Bangladesh.
Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, 9100, Bangladesh.
出版信息
Virol Sin. 2015 Oct;30(5):326-43. doi: 10.1007/s12250-015-3624-1. Epub 2015 Oct 20.
Every year, millions of individuals throughout the world are seriously affected by dengue virus. The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern. Not only does dengue cause fatalities but it also has a profoundly negative economic impact. In recent decades, extensive research has been performed on epidemiology, vector biology, life cycle, pathogenesis, vaccine development and prevention. Although dengue research is still not at a stage to suggest definite hopes of a cure, encouraging significant advances have provided remarkable progress in the fight against infection. Recent developments indicate that both anti-viral drug and vaccine research should be pursued, in parallel with vector control programs.
每年，全球数以百万计的人受到登革热病毒的严重影响。由于缺乏疫苗和抗病毒药物，这种通过蚊子传播的疾病已成为严重的健康问题。登革热不仅会导致死亡，还会产生深远的负面经济影响。近几十年来，人们在流行病学、病媒生物学、生命周期、发病机制、疫苗研发和预防等方面进行了广泛的研究。尽管登革热研究尚未达到能够明确提出治愈希望的阶段，但令人鼓舞的重大进展为抗击感染提供了显著进步。最近的进展表明，抗病毒药物和疫苗研究应与病媒控制计划并行推进。
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