普罗吉尼卡ID CORE XT概述：一种基于微流控芯片系统的自动化基因分型平台。

An overview of the Progenika ID CORE XT: an automated genotyping platform based on a fluidic microarray system.

作者信息

Goldman Mindy, Núria Núria, Castilho Lilian M

机构信息

MD (corresponding author), Medical Services and Innovation, Canadian Blood Services, 1800 Alta Vista Drive, Ottawa, Ontario, Canada, K1G 4J5.

PhD, Immunohematology Laboratory, Banc de Sang i Teixits, Barcelona, Spain.

出版信息

Immunohematology. 2015;31(2):62-8.

PMID:26495891

Abstract

Automated testing platforms facilitate the introduction of red cell genotyping of patients and blood donors. Fluidic microarray systems, such as Luminex XMAP (Austin, TX), are used in many clinical applications, including HLA and HPA typing. The Progenika ID CORE XT (Progenika Biopharma-Grifols, Bizkaia, Spain) uses this platform to analyze 29 polymorphisms determining 37 antigens in 10 blood group systems. Once DNA has been extracted, processing time is approximately 4 hours. The system is highly automated and includes integrated analysis software that produces a file and a report with genotype and predicted phenotype results.

摘要

自动化检测平台有助于对患者和献血者进行红细胞基因分型。流体微阵列系统，如Luminex XMAP（德克萨斯州奥斯汀），被用于许多临床应用，包括HLA和HPA分型。Progenika ID CORE XT（西班牙比斯开省Progenika生物制药公司-基立福）使用该平台分析29个多态性，这些多态性决定了10个血型系统中的37种抗原。一旦提取出DNA，处理时间约为4小时。该系统高度自动化，包括集成分析软件，可生成包含基因型和预测表型结果的文件和报告。