箭毒生物碱：马蒂斯族毒箭的成分

Curare Alkaloids: Constituents of a Matis Dart Poison.

作者信息

Malca Garcia Gonzalo R, Hennig Lothar, Shelukhina Irina V, Kudryavtsev Denis S, Bussmann Rainer W, Tsetlin Victor I, Giannis Athanassios

机构信息

Institut für Organische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig , Johannisallee 29, 04103 Leipzig, Germany.

Department of Molecular Basis of Neurosignaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences , 117997 Moscow, Russia.

出版信息

J Nat Prod. 2015 Nov 25;78(11):2537-44. doi: 10.1021/acs.jnatprod.5b00457. Epub 2015 Oct 23.

DOI:10.1021/acs.jnatprod.5b00457

PMID:26496427

Abstract

A phytochemical study of dart and arrow poison from the Matis tribe led to the identification of D-(-)-quinic acid, L-malic acid, ethyldimethylamine, magnoflorine, and five new bisbenzyltetrahydroisoquinoline alkaloids (BBIQAs), 1-5. D-Tubocurarine could not be identified among these products. BBIQA (3) contains a unique linkage at C-8 and C-11'. All structures were characterized by a combination of NMR and HRESIMS data. The effects of Matis poison and individual BBIQAs (1-3) on rat muscle nAChR expressed in Xenopus oocytes have been investigated using the two-electrode voltage clamp technique.

摘要

对马蒂斯部落的飞镖和箭毒进行的植物化学研究，鉴定出了D-(-)-奎尼酸、L-苹果酸、乙二甲基胺、厚朴酚，以及五种新的双苄基四氢异喹啉生物碱（BBIQAs），即1-5。在这些产物中未鉴定出筒箭毒碱。BBIQA（3）在C-8和C-11'处含有独特的连接。所有结构均通过核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）数据相结合进行表征。利用双电极电压钳技术研究了马蒂斯毒药和单个BBIQAs（1-3）对非洲爪蟾卵母细胞中表达的大鼠肌肉烟碱型乙酰胆碱受体（nAChR）的影响。