颅内压升高对眼前庭诱发肌源性电位频率调谐的影响。

The Effect of Increasing Intracranial Pressure on Ocular Vestibular-Evoked Myogenic Potential Frequency Tuning.

作者信息

Jerin Claudia, Wakili Reza, Kalla Roger, Gürkov Robert

机构信息

1German Center for Vertigo and Balance Disorders, Grosshadern Medical Center, University of Munich, Munich, Germany; 2Department of Medicine I, Klinikum Grosshadern, University of Munich and Munich Heart Alliance (Deutsches Zentrum für Herz-Kreislauf-Forschung), Munich, Germany; 3Department of Neurology, Inselspital Bern, Bern, Switzerland; and 4Department of Otorhinolaryngology-Head and Neck Surgery, Grosshadern Medical Center, University of Munich, Munich, Germany.

出版信息

Ear Hear. 2015 Nov-Dec;36(6):e336-41. doi: 10.1097/AUD.0000000000000190.

DOI:10.1097/AUD.0000000000000190

PMID:26502192

Abstract

OBJECTIVE

Ocular vestibular-evoked myogenic potentials (oVEMPs) represent extraocular muscle activity in response to vestibular stimulation. The authors sought to investigate whether posture-induced increase of the intracranial pressure (ICP) modulated oVEMP frequency tuning, that is, the amplitude ratio between 500-Hz and 1000-Hz stimuli.

DESIGN

Ten healthy subjects were enrolled in this study. The subjects were positioned in the horizontal plane (0 degree) and in a 30-degree head-downwards position to elevate the ICP. In both positions, oVEMPs were recorded using 500-Hz and 1000-Hz air-conducted tone bursts.

RESULTS

When tilting the subject from the horizontal plane to the 30-degree head-down position, oVEMP amplitudes in response to 500-Hz tone bursts distinctly decreased (3.40 μV versus 2.06 μV; p < 0.001), whereas amplitudes to 1000 Hz were only slightly diminished (2.74 μV versus 2.48 μV; p = 0.251). Correspondingly, the 500/1000-Hz amplitude ratio significantly decreased when tilting the subjects from 0- to 30-degree inclination (1.59 versus 1.05; p = 0.029). Latencies were not modulated by head-down position.

CONCLUSIONS

Increasing ICP systematically alters oVEMPs in terms of absolute amplitudes and frequency tuning characteristics. oVEMPs are therefore in principle suited for noninvasive ICP monitoring.

摘要

目的

眼前庭诱发肌源性电位（oVEMP）代表了眼外肌对前庭刺激的反应活动。作者试图研究姿势诱导的颅内压（ICP）升高是否会调节oVEMP频率调谐，即500赫兹和1000赫兹刺激之间的幅度比。

设计

本研究招募了10名健康受试者。受试者分别处于水平面（0度）和头向下30度的位置以升高颅内压。在这两种姿势下，均使用500赫兹和1000赫兹的气导短纯音记录oVEMP。

结果

当受试者从水平面倾斜至头向下30度位置时，对500赫兹短纯音刺激的oVEMP幅度明显降低（3.40微伏对2.06微伏；p<0.001），而对1000赫兹刺激的幅度仅略有减小（2.74微伏对2.48微伏；p=0.251）。相应地，当受试者从0度倾斜至30度时，500/1000赫兹幅度比显著降低（1.59对1.05；p=0.029）。潜伏期不受头向下姿势的调节。