Albergo José I, Farfalli Germán L, Ayerza Miguel A, Muscolo Domingo L, Aponte-Tinao Luis A
Servicio de Ortopedia y Traumatología, Hospital Italiano de Buenos Aires, Argentina. E-mail:
Medicina (B Aires). 2015;75(5):303-6.
The objective of the study was to analyze a group of patients with low grade parosteal osteosarcoma treated with limb salvage surgery and reconstructed with bone allograft. A retrospective review from our oncologic data base between 1980 and 2010 was done and all patients with diagnosis of low grade parosteal osteosarcoma, treated with limb salvage surgery and reconstructed with allograft were included. Twenty-two patients were included for the analysis. The mean age was 32±11 years (10-59) y the mean follow-up 93±69 months (8-237). Ten year overall survival of the series was 91% (95% CI: 79-100). Four patients developed local recurrence, 2 of them histological classified after the resection dedifferentiated parosteal osteosarcoma. Two patients developed distant recurrence, being the lung the only site of metastasis. Ten year limb salvage reconstruction survival was 65% (95% CI: 44-86). Long term survival rate in low grade parosteal osteosarcoma is over 90%. Surgical resection wide margin should be the elective treatment and biological limb salvage reconstruction is a good alternative.
本研究的目的是分析一组接受保肢手术并用同种异体骨移植重建的低级别骨旁骨肉瘤患者。对我们肿瘤数据库中1980年至2010年间的数据进行了回顾性分析,纳入了所有诊断为低级别骨旁骨肉瘤、接受保肢手术并用同种异体骨移植重建的患者。22例患者纳入分析。平均年龄为32±11岁(10 - 59岁),平均随访时间为93±69个月(8 - 237个月)。该系列患者的10年总生存率为91%(95%置信区间:79 - 100)。4例患者出现局部复发,其中2例在切除后组织学分类为去分化骨旁骨肉瘤。2例患者出现远处复发,仅肺部转移。10年保肢重建生存率为65%(95%置信区间:44 - 86)。低级别骨旁骨肉瘤的长期生存率超过90%。手术切除切缘阴性应作为首选治疗方法,生物保肢重建是一种很好的选择。