儿童骨关节结核中的淋巴细胞/单核细胞比值：重新审视的血液生物标志物
Lymphocyte/monocyte ratio in osteoarticular tuberculosis in children: a haematological biomarker revisited.
作者信息
Agarwal Anil, Bhat Mohd Shafi, Kumar Anubrat, Shaharyar Abbas, Mishra Madhusudhan, Yadav Rajeev
机构信息
Specialist, Department of Pediatric Orthopedics, Chacha Nehru Bal Chikitsalaya, Delhi, India
Senior Resident, Department of Paediatric Orthopedics, Chacha Nehru Bal Chikitsalaya, Delhi, India.
出版信息
Trop Doct. 2016 Apr;46(2):73-7. doi: 10.1177/0049475515609244. Epub 2015 Oct 25.
INTRODUCTION
*Work attributed to Department of Pediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi-110031(India)This study tested the hypothesis whether the lymphocyte/monocyte ratio (L/M ratio) altered significantly during treatment of paediatric osteoarticular tuberculosis (OATB) for it to be a useful monitor of the response to therapy.
MATERIAL AND METHODS
Thirty immunocompetent paediatric patients with OATB treated with 6 months of uninterrupted multidrug anti-tubercular treatment with resultant clinical and radiological healing of the lesion were included. Haemoglobin, total leucocyte, monocyte and lymphocyte count, and erythrocyte sedimentation rate (ESR) were collected at 0, 2 and 6 months, and were analysed.
RESULTS
The L/M ratio altered from high (11) at the start of treatment towards normalisation (9) at 2 months and (7.7) at 6 months. There was no correlation with declining ESR levels.
CONCLUSIONS
The L/M ratio may have potential as an effective biomarker response.
引言
*作品归属印度德里110031吉塔殖民地查查·尼赫鲁儿童医院小儿骨科部门。本研究检验了一个假设，即在小儿骨关节结核（OATB）治疗期间淋巴细胞/单核细胞比率（L/M比率）是否会发生显著变化，从而使其成为治疗反应的有用监测指标。
材料与方法
纳入30例免疫功能正常的OATB小儿患者，接受为期6个月的不间断多药抗结核治疗，病变最终实现临床和影像学愈合。在第0、2和6个月收集血红蛋白、全白细胞、单核细胞和淋巴细胞计数以及红细胞沉降率（ESR），并进行分析。
结果
L/M比率从治疗开始时的高水平（11）在2个月时趋于正常（9），在6个月时为（7.7）。与ESR水平下降无关。
结论
L/M比率可能有潜力作为一种有效的生物标志物反应。
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