同一患者发生的胰腺和胆管导管内乳头状肿瘤的GNAS和KRAS突变分析：病例报告

GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report.

作者信息

Date Kenjiro, Ohtsuka Takao, Fujimoto Takaaki, Gotoh Yoshitaka, Nakashima Yohei, Kimura Hideyo, Matsunaga Taketo, Mori Yasuhisa, Mochidome Naoki, Miyazaki Tetsuyuki, Oda Yoshinao, Tanaka Masao, Nakamura Masafumi

机构信息

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

出版信息

Pancreatology. 2015 Nov-Dec;15(6):713-6. doi: 10.1016/j.pan.2015.09.013. Epub 2015 Oct 22.

DOI:10.1016/j.pan.2015.09.013

PMID:26506885

Abstract

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas and intraductal papillary neoplasm of the bile duct (IPNB) are considered as counterparts of each other, and it is suggested that these two entities have similar molecular alteration pathways. However, the occurrence of IPMN of the pancreas and IPNB in the same patient is rare. We report a surgical case of a 69-year-old woman who developed invasive IPMN of the pancreas and underwent pancreatectomy, 6 months after hepatic resection of invasive IPNB. Molecular analysis revealed GNAS/KRAS mutation in both invasive IPMN of the pancreas and IPNB. This is believed to be the first case report investigating GNAS/KRAS mutational status in both IPMN of the pancreas and IPNB developing in the same patient, and these two entities may show similar molecular alternations.

摘要

胰腺导管内乳头状黏液性肿瘤（IPMN）和胆管导管内乳头状肿瘤（IPNB）被认为是彼此的对应物，并且提示这两种实体具有相似的分子改变途径。然而，同一患者同时发生胰腺IPMN和IPNB的情况罕见。我们报告一例69岁女性的手术病例，该患者在肝切除侵袭性IPNB 6个月后发生了胰腺侵袭性IPMN并接受了胰腺切除术。分子分析显示胰腺侵袭性IPMN和IPNB均存在GNAS/KRAS突变。这被认为是首例调查同一患者发生的胰腺IPMN和IPNB中GNAS/KRAS突变状态的病例报告，并且这两种实体可能显示相似的分子改变。