韩国注意缺陷多动障碍儿童中儿茶酚-O-甲基转移酶Val158-Met多态性与干扰控制能力降低的关联。
Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder.
作者信息
Park Subin, Park Jong-Eun, Yoo Hee Jeong, Kim Jae-Won, Cheong Jae Hoon, Han Doug Hyun, Kim Yeni, Kim Bung-Nyun
机构信息
Department of Psychiatry, Seoul National Hospital, Seoul, Republic of Korea.
Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
出版信息
Psychiatry Investig. 2015 Oct;12(4):563-5. doi: 10.4306/pi.2015.12.4.563. Epub 2015 Sep 30.
OBJECTIVE
We tested for association of the catechol-O-methyltransferase (COMT) Val(158)-Met (rs4680) polymorphism with attention-deficit hyperactivity disorder (ADHD) using family-based test in Korean trios.
METHODS
A total of 181 subjects with ADHD along with both of their biological parents were recruited from University Hospitals in Korea. We performed a transmission disequilibrium test (TDT) on 181 trios.
RESULTS
In the TDT, we found the over-transmission of the Val allele in children with ADHD (χ(2)=4.21, p=0.040).
CONCLUSION
These results suggest that the COMT Val158-Met polymorphism is associated with ADHD among the Korean population. However, this study must be replicated in larger populations.
目的
我们在韩国三口之家中采用基于家系的检验方法，检测儿茶酚-O-甲基转移酶（COMT）Val(158)-Met（rs4680）多态性与注意力缺陷多动障碍（ADHD）之间的关联。
方法
从韩国大学医院招募了总共181名患有ADHD的受试者及其双亲。我们对181个三口之家进行了传递不平衡检验（TDT）。
结果
在TDT中，我们发现ADHD儿童中Val等位基因过度传递（χ(2)=4.21，p=0.040）。
结论
这些结果表明，COMT Val158-Met多态性与韩国人群中的ADHD相关。然而，本研究必须在更大规模人群中重复进行。
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