Treadway J L, Young J C
Department of Health Sciences, Sargent College of Allied Health Professions, Boston University, MA 02215.
Med Sci Sports Exerc. 1989 Apr;21(2):140-5.
Glucose uptake by muscle is stimulated by exercise. However, during pregnancy, insulin resistance develops in maternal skeletal muscle as a mechanism to spare glucose for use by the developing fetus. The purpose of this study was to determine whether a bout of exercise adversely affects glucose availability to the fetus by increasing glucose uptake in maternal muscle tissue. Pregnant (P) and nonpregnant (NP) rats were divided into rest and exercise groups. Immediately following a 50-min treadmill run, a bolus of glucose (1 g.kg-1) and tracer [1-3H]2-deoxyglucose was injected i.v., and rats underwent a 60-min i.v. glucose tolerance test (IVGTT), after which they were sacrificed. Although glucose levels were lower for P vs NP rats at all time points, prior exercise did not affect glucose levels in either P or NP rats. Plasma insulin levels were augmented in P compared with NP rats and were not significantly altered by prior exercise. Glucose/tracer accumulation was enhanced in red and white gastrocnemius in both P and NP rats, and in soleus of NP rats, by exercise. However, glucose/tracer accumulation in the fetus was decreased by 40% (P less than 0.01) in the exercised dams. These results indicate that uptake of glucose by the fetus is compromised following exercise, as a result of increased glucose uptake by maternal skeletal muscles.
运动可刺激肌肉摄取葡萄糖。然而，在怀孕期间，母体骨骼肌会出现胰岛素抵抗，这是一种为发育中的胎儿节省葡萄糖以供其使用的机制。本研究的目的是确定一次运动是否会因增加母体肌肉组织对葡萄糖的摄取而对胎儿的葡萄糖供应产生不利影响。将怀孕（P）和未怀孕（NP）的大鼠分为休息组和运动组。在进行50分钟的跑步机跑步后，立即静脉注射大剂量葡萄糖（1 g·kg-1）和示踪剂[1-3H]2-脱氧葡萄糖，然后大鼠接受60分钟的静脉葡萄糖耐量试验（IVGTT），之后将它们处死。尽管在所有时间点P组大鼠的葡萄糖水平均低于NP组大鼠，但先前的运动并未影响P组或NP组大鼠的葡萄糖水平。与NP组大鼠相比，P组大鼠的血浆胰岛素水平升高，且先前的运动并未使其发生显著改变。运动可增强P组和NP组大鼠的红色和白色腓肠肌以及NP组大鼠比目鱼肌中的葡萄糖/示踪剂积累。然而，在运动的母鼠中，胎儿的葡萄糖/示踪剂积累减少了40%（P<0.01）。这些结果表明，运动后胎儿对葡萄糖的摄取受到损害，这是母体骨骼肌对葡萄糖摄取增加的结果。
