源自四氢嘧啶衍生物的新型稠合杂环化合物的抗氧化活性
Antioxidant Activity of Novel Fused Heterocyclic Compounds Derived from Tetrahydropyrimidine Derivative.
作者信息
Salem Marwa Sayed, Farhat Mahmoud, Errayes Asma Omar, Madkour Hassan Mohamed Fawzy
机构信息
Synthetic Organic Chemistry Laboratory, Chemistry Department, Faculty of Science, Ain Shams University.
出版信息
Chem Pharm Bull (Tokyo). 2015;63(11):866-72. doi: 10.1248/cpb.c15-00452.
6-(Benzo[d][1,3]dioxol-5-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile has been utilized for synthesis of the fused heterocyclic compounds namely thiazolopyrimidines, tetrazolopyrimidine, pyrimidoquinazoline, pyrimidothiazolopyrimidine, pyrimidothiazolotriazine and pyrrolothiazolopyrimidine derivatives. The newly synthesized compounds were characterized by IR, (1)H-NMR, (13)C-NMR, and mass spectral data. Antioxidant activities of all synthesized compounds were investigated.
6-（苯并[d][1,3]二氧杂环戊烯-5-基）-4-氧代-2-硫代-1,2,3,4-四氢嘧啶-5-腈已被用于合成稠合杂环化合物，即噻唑并嘧啶、四唑并嘧啶、嘧啶并喹唑啉、嘧啶并噻唑并嘧啶、嘧啶并噻唑并三嗪和吡咯并噻唑并嘧啶衍生物。通过红外光谱、¹H-核磁共振、¹³C-核磁共振和质谱数据对新合成的化合物进行了表征。研究了所有合成化合物的抗氧化活性。
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