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一例罕见的伴有间变性淋巴瘤激酶(ALK)重排的肺多形性癌

A Rare Case of Pleomorphic Carcinoma of the Lung Harboring an Anaplastic Lymphoma Kinase (ALK) Rearrangement.

作者信息

Shiroyama Takayuki, Tanaka Ayako, Tamiya Motohiro, Hamaguchi Masanari, Osa Akio, Takeoka Sawa, Tani Eriko, Azuma Yuichiro, Morishita Naoko, Suzuki Hidekazu, Okamoto Norio, Kimura Kenji, Kadota Yoshihisa, Kawahara Kunimitsu, Hirashima Tomonori, Kawase Ichiro

机构信息

Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan.

出版信息

Intern Med. 2015;54(21):2741-3. doi: 10.2169/internalmedicine.54.4474. Epub 2015 Nov 1.

Abstract

Molecular testing for anomalies, such as epidermal growth factor receptor mutations and anaplastic lymphoma kinase (ALK) rearrangement, is part of the current standard of care for non-small cell lung cancer, particularly adenocarcinoma. ALK rearrangement occurs most frequently in adenocarcinoma cells and rarely in non-adenocarcinoma cells. We herein report a rare case of pleomorphic lung carcinoma with ALK rearrangement in both its adenocarcinoma and spindle cell components. This case suggests the possibility of ALK rearrangement in pleomorphic carcinoma.

摘要

对异常情况进行分子检测,如表皮生长因子受体突变和间变性淋巴瘤激酶(ALK)重排,是目前非小细胞肺癌,尤其是腺癌治疗标准的一部分。ALK重排最常发生于腺癌细胞,很少发生于非腺癌细胞。我们在此报告一例罕见的多形性肺癌病例,其腺癌和梭形细胞成分均存在ALK重排。该病例提示多形性癌存在ALK重排的可能性。

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