炔基羰基复分解反应作为制备4-酰基色烯的一种方法：（±）-鱼藤素和（±）-蒙杜色酮的合成。
Alkyne Carbonyl Metathesis As a Means To Make 4-Acyl Chromenes: Syntheses of (±)-Deguelin and (±)-Munduserone.
作者信息
Nayak Maloy, Kim Ikyon
机构信息
College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University 85 Songdogwahak-ro, Yeonsu-gu, Incheon 406-840, Republic of Korea.
出版信息
J Org Chem. 2015 Nov 20;80(22):11460-7. doi: 10.1021/acs.joc.5b02160. Epub 2015 Nov 11.
A highly convergent synthetic approach to rotenoid natural products is described. Successful pairing of two building blocks for Sonogashira cross-coupling and intramolecular alkyne carbonyl metathesis allows ready access to 4-acylchromene, a key substructure of these natural products, leading to syntheses of (±)-deguelin and (±)-munduserone in high overall yields.
描述了一种用于鱼藤酮类天然产物的高度收敛的合成方法。成功地将用于Sonogashira交叉偶联和分子内炔基羰基复分解的两个结构单元配对，使得能够容易地获得4-酰基色烯，这些天然产物的关键亚结构，从而以高总收率合成（±）-鱼藤素和（±）-芒杜色酮。
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