Polo Valentina, Zago Giulia, Frega Stefano, Canova Fabio, Bonanno Laura, Favaretto Adolfo, Bonaldi Laura, Bertorelle Roberta, Conte PierFranco, Pasello Giulia
Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Division of Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.
Am J Case Rep. 2015 Nov 3;16:782-9. doi: 10.12659/ajcr.894426.
Lung cancer in young patients is quite uncommon; clinical presentation and outcome in this population compared to the older group are not yet well defined and data about this setting are mostly single-institutional retrospective analyses.
We report here a case of a very young woman with diagnosis of early-stage lung adenocarcinoma harboring EML4-ALK rearrangement; she underwent radical surgery and adjuvant chemotherapy according to the pathologic stage. Potential risk factors for lung cancer in our patient are discussed and clinico-pathologic features and outcomes of lung cancer in the young population compared to the elderly are reviewed through discussing studies with sample sizes larger than 100 patients.
A wide clinical overview should be performed when lung cancer is diagnosed in a young patient. Large-population studies are required to define the molecular signature and clinical behavior of lung cancer in young patients.
年轻患者的肺癌相当罕见；与老年组相比，该人群的临床表现和预后尚未明确界定，关于这一情况的数据大多是单机构回顾性分析。
我们在此报告一例非常年轻的女性，诊断为伴有EML4-ALK重排的早期肺腺癌；她根据病理分期接受了根治性手术和辅助化疗。讨论了我们患者患肺癌的潜在风险因素，并通过讨论样本量大于100例患者的研究，回顾了年轻人群与老年人群肺癌的临床病理特征和预后。
当诊断出年轻患者患有肺癌时，应进行全面的临床概述。需要开展大规模人群研究来确定年轻患者肺癌的分子特征和临床行为。
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