MTA1在结直肠癌中上调且与淋巴转移呈负相关。
MTA1 Is Up-regulated in Colorectal Cancer and Is Inversely Correlated with Lymphatic Metastasis.
作者信息
Li Jun, Ye Lin, Sun Ping-Hui, Satherley Lucy, Hargest Rachel, Zhang Zhongtao, Jiang Wen G
机构信息
Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K. Department of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. China.
Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.
出版信息
Cancer Genomics Proteomics. 2015 Nov-Dec;12(6):339-45.
BACKGROUND
Metastasis-associated protein 1 (MTA1) plays an important role in tumourigenesis and progression of certain cancer types. In the current study, we analyzed the relationship between MTA1 expression and disease progression of colorectal cancer (CRC).
MATERIALS AND METHODS
CRC tissues (n=93) and adjacent normal colorectal tissues (n=70) were analyzed by quantitative real-time polymerase chain reaction. MTA1 knockdown was established in RKO and HT115 cells using MTA1 siRNA.
RESULTS
The expression of MTA1 was significantly increased in CRC tissues compared to paired normal colorectal tissues, but decreased expression of MTA1 was correlated with poor prognosis (higher lymph node involvement stage, TNM stage, local invasion and recurrence) that was associated with increased expression of VEGFC and -D and the receptor VEGFR3.
CONCLUSION
MTA1 is up-regulated in CRC. MTA1 expression is inversely associated with lymphatic metastases and the expression of VEGFC, VEGFD and VEGFR3.
背景
转移相关蛋白1（MTA1）在某些癌症类型的肿瘤发生和进展中起重要作用。在本研究中，我们分析了MTA1表达与结直肠癌（CRC）疾病进展之间的关系。
材料与方法
采用定量实时聚合酶链反应分析93例CRC组织和70例相邻正常结直肠组织。使用MTA1 siRNA在RKO和HT115细胞中建立MTA1敲低。
结果
与配对的正常结直肠组织相比，CRC组织中MTA1的表达显著增加，但MTA1表达降低与预后不良（更高的淋巴结受累分期、TNM分期、局部侵袭和复发）相关，这与VEGFC和 -D以及受体VEGFR3的表达增加有关。
结论
MTA1在CRC中上调。MTA1表达与淋巴转移以及VEGFC、VEGFD和VEGFR3的表达呈负相关。
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