帕金森病的干细胞移植治疗
Stem cell transplantation therapy in Parkinson's disease.
作者信息
Fu Mu-Hui, Li Chia-Ling, Lin Hsiu-Lien, Chen Pei-Chun, Calkins Marcus J, Chang Yu-Fan, Cheng Pei-Hsun, Yang Shang-Hsun
机构信息
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101 Taiwan.
Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 83301 Taiwan.
出版信息
Springerplus. 2015 Oct 13;4:597. doi: 10.1186/s40064-015-1400-1. eCollection 2015.
Ineffective therapeutic treatments and inadequate repair ability in the central nervous system are disturbing problems for several neurological diseases. Fortunately, the development of clinically applicable populations of stem cells has provided an avenue to overcome the failure of endogenous repair systems and substitute new cells into the damaged brain. However, there are still several existing obstacles to translating into clinical application. Here we review the stem-cell based therapies for Parkinson's disease and discuss the potential advantages and drawbacks. We hope this review may provide suggestions for viable strategies to overcome the current technical and biological issues associated with the application of stem cells in Parkinson's disease.
中枢神经系统中无效的治疗方法和不足的修复能力是几种神经疾病令人困扰的问题。幸运的是，临床适用的干细胞群体的发展为克服内源性修复系统的失败以及将新细胞替代到受损大脑中提供了一条途径。然而，转化为临床应用仍存在一些现有障碍。在此，我们综述基于干细胞治疗帕金森病的方法，并讨论其潜在的优缺点。我们希望这篇综述可为克服目前与干细胞在帕金森病应用相关的技术和生物学问题的可行策略提供建议。
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