Born Willi K, Roark Christina L, Jin Niyun, Wands J M, Kemal Aydintug M, Huang Yafei, Chain Jennifer L, Hahn Youn-Soo, Simonian Philip L, Fontenot Andrew P, O'Brien Rebecca L
Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206 and University of Colorado Denver, Aurora, CO 80045, USA.
Department of Pediatrics, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 361-711 and 240, Korea.
Open Immunol J. 2009;2:143-150. doi: 10.2174/1874226200902010143. Epub 2009 Oct 23.
The resident population of γδ T cells in the normal lung is small but during lung inflammation, γδ T cells can increase dramatically. Histological analysis reveals diverse interactions between γδ T cells and other pulmonary leukocytes. Studies in animal models show that γδ T cells play a role in allergic lung inflammation where they can protect normal lung function, that they also are capable of resolving infection-induced pulmonary inflammation, and that they can help preventing pulmonary fibrosis. Lung inflammation threatens vital lung functions. Protection of the lung tissues and their functions during inflammation is the net-effect of opposing influences of specialized subsets of γδ T cells as well as interactions of these cells with other pulmonary leukocytes.
正常肺组织中γδT细胞的常驻数量很少，但在肺部发生炎症时，γδT细胞数量会急剧增加。组织学分析揭示了γδT细胞与其他肺白细胞之间存在多种相互作用。动物模型研究表明，γδT细胞在过敏性肺部炎症中发挥作用，能够保护正常肺功能，还能够消除感染引起的肺部炎症，并且有助于预防肺纤维化。肺部炎症会威胁到重要的肺功能。在炎症期间保护肺组织及其功能是γδT细胞特定亚群的相反影响以及这些细胞与其他肺白细胞相互作用的综合结果。
Zotero 插件