比较苄普地尔和茚丙胺预防心脏和主动脉手术后房颤的效果：一项前瞻性随机研究。
Comparison of the effects of bepridil and aprindine for the prevention of atrial fibrillation after cardiac and aortic surgery: A prospective randomized study.
作者信息
Ozawa Mahito, Komatsu Takashi, Sato Yoshihiro, Kunugita Fusanori, Tachibana Hideaki, Tashiro Atsushi, Okabayashi Hitoshi, Nakamura Motoyuki
机构信息
Division of Cardioangiology, Nephrology and Endocrinology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Morioka, Japan.
Department of Cardiovascular Surgery, Iwate Medical University School of Medicine, Morioka, Japan.
出版信息
J Arrhythm. 2015 Oct;31(5):302-6. doi: 10.1016/j.joa.2015.04.003. Epub 2015 May 16.
BACKGROUND
Approximately one-third of the patients undergoing cardiovascular surgery reportedly experience paroxysmal atrial fibrillation (AF) during the postoperative period. However, the usefulness of antiarrhythmic drugs for preventing postoperative AF recurrence in the Japanese population has not been extensively studied.
METHODS
From a total of 118 patients who developed postoperative paroxysmal AF between April 2009 and March 2011, 72 patients (45 men, mean age 68±8 years) requiring treatment for postoperative AF due to symptoms lasting ≥30 min were enrolled to prospectively investigate the efficacy of oral bepridil (100 mg/day, n=37) or aprindine (40 mg/day, n=35).
RESULT
The AF recurrence-free survival rates at 1, 3, 7, and 14 days were 100%, 94%, 57%, and 49%, respectively, in the aprindine group, and 100%, 97%, 86%, and 76%, respectively, in the bepridil group (P=0.028, aprindine vs. bepridil).
CONCLUSION
Bepridil, at a fixed dose of 100 mg/day, was considered to be more effective than a routine dose of aprindine for the prevention of postoperative AF recurrence.
背景
据报道，约三分之一接受心血管手术的患者在术后会发生阵发性心房颤动（AF）。然而，抗心律失常药物在日本人群中预防术后AF复发的有效性尚未得到广泛研究。
方法
在2009年4月至2011年3月期间发生术后阵发性AF的118例患者中，纳入72例（45例男性，平均年龄68±8岁）因症状持续≥30分钟而需要治疗术后AF的患者，前瞻性研究口服苄普地尔（100mg/天，n=37）或安搏律定（40mg/天，n=35）的疗效。
结果
安搏律定组在1、3、7和14天的无AF复发生存率分别为100%、94%、57%和49%，苄普地尔组分别为100%、97%、86%和76%（安搏律定与苄普地尔比较，P=0.028）。
结论
固定剂量为100mg/天的苄普地尔在预防术后AF复发方面被认为比常规剂量的安搏律定更有效。
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