冠状动脉临界病变患者中内皮微粒与一氧化氮、内皮型一氧化氮合酶、内皮素-1及血流储备分数的相关性
Association of endothelial microparticle with NO, eNOS, ET-1, and fractional flow reserve in patients with coronary intermediate lesions.
作者信息
Song Rui, Chou Yuan I Scarlet, Kong Jinge, Li Jizhao, Pan Bing, Cui Ming, Zhou Enchen, Zhang Yongzhen, Zheng Lemin
机构信息
a Department of Cardiology , Peking University Third Hospital , Beijing , P.R. China .
b The Neuroscience Research Institute & Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University , Beijing , P.R. China , and.
出版信息
Biomarkers. 2015;20(6-7):429-35. doi: 10.3109/1354750X.2015.1094140. Epub 2015 Nov 10.
Endothelial microparticle (EMP) is a biomarker for endothelial dysfunction. The aim of this study is to investigate the utility of EMP in evaluating coronary intermediate lesions. Participants included 49 patients with coronary intermediate lesions and 24 subjects with normal coronary arteries. Among these subjects, 28 patients accepted fractional flow reserve (FFR). Results showed that level of EMP was significantly higher in the intermediate lesion group. No correlation was found between EMP and FFR value, suggesting that circulating EMP is a systemic marker rather than a focal one.
内皮微粒（EMP）是内皮功能障碍的生物标志物。本研究旨在探讨EMP在评估冠状动脉中度病变中的效用。参与者包括49例冠状动脉中度病变患者和24例冠状动脉正常的受试者。在这些受试者中，28例患者接受了血流储备分数（FFR）检查。结果显示，中度病变组的EMP水平显著更高。未发现EMP与FFR值之间存在相关性，这表明循环EMP是一种全身性标志物而非局部性标志物。
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