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尿调蛋白、肾功能、心血管疾病和死亡率。

Uromodulin, kidney function, cardiovascular disease, and mortality.

机构信息

Institute of Physiology, University of Zurich, Zurich, Switzerland.

University Institute of Social and Preventive Medicine, Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois), Lausanne, Switzerland.

出版信息

Kidney Int. 2015 Nov;88(5):944-6. doi: 10.1038/ki.2015.267.

Abstract

Uromodulin (Tamm-Horsfall protein) is exclusively produced by the kidney and is the most abundant protein excreted in normal urine. The level of uromodulin in urine could represent a useful biomarker for renal tubular function. The study of Garimella et al. adds elements into the debate, by suggesting that, in elderly adults, low urinary uromodulin concentrations in spot urine identify people at risk of progressive kidney disease and mortality above and beyond established markers of kidney disease.

摘要

尿调蛋白(Tamm-Horsfall 蛋白)是肾脏特有的一种蛋白,也是正常尿液中排泄量最多的蛋白。尿调蛋白的水平可作为反映肾小管功能的有用生物标志物。Garimella 等人的研究通过提示在老年人中,单次尿液样本中尿调蛋白浓度低可识别出患有进展性肾病和死亡率风险增加的人群,这为该争论增添了新内容,而这种风险超出了已确立的肾脏疾病标志物的范围。

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