Corte Helene, Maggiori Leon, Treton Xavier, Lefevre Jeremie H, Ferron Marianne, Panis Yves
*Department of Colorectal Surgery, Beaujon Hospital, Assistance publique-Hôpitaux de Paris, Université Paris VII, Clichy, France †Department of Gastroenterology and Nutritive Assistance, Beaujon Hospital, Assistance publique-Hôpitaux de Paris, Université Paris VII, Clichy, France.
Ann Surg. 2015 Nov;262(5):855-60; discussion 860-1. doi: 10.1097/SLA.0000000000001461.
The aim of this study was to assess results of surgery for rectovaginal fistula (RVF) and prognostic factors for success.
Management of RVF remains challenging and numerous surgical options are available. Few large reports of RVF are available and success prognostic factors remain unknown.
All patients operated for RVF from 1996 to 2014 were included.
Seventy-nine patients presented RVF due to Crohn disease in 34 (43%), postoperative in 25 (32%), obstetrical in 7 (9%), radiation proctitis in 4 (5%), and miscellaneous in 9 (11%). A total of 286 procedures (132 with associated stoma, 46%) were performed including 217 conservative (76%) [seton drainage (n = 59; 21%), vaginal (n = 49, 17%) or rectal advancement flap (n = 46; 16%), diverting stoma only (n = 27; 9%), plug (n = 15; 5%), glue (n = 13; 5%), or others (n = 8, 3%)]; and 69 major procedures (24%) [gracilis muscle interposition (n = 32; 11%), coloanal or colorectal anastomosis (n = 19; 7%) including 11 delayed anastomosis with colonic pull-through, biomesh interposition (n = 9, 3%), and abdominoperineal resection (n = 9; 3%)]. After a mean follow-up of 33 months, overall success rate was 57 of 79 (72%). Per-procedure-based multivariate analysis identified major procedure [odds ratio (OR): 6.4 (2.9-14.2); P < 0.001], diverting stoma [OR: 3.5 (1.4-8.7); P = 0.009], less than 9 months between diagnosis and first surgery [OR: 2.3 (1.1-5.3); P = 0.046], and first surgery in our institution [OR: 3.2 (1.5-6.9); P = 0.003], as independent factors for success.
Our study suggested that aggressive surgical treatment of RVF, including early use of temporary stoma and major procedure in case of failure of previous local treatment, leads to high success rates.
本研究旨在评估直肠阴道瘘(RVF)手术的结果及成功的预后因素。
RVF的治疗仍然具有挑战性,有多种手术选择。关于RVF的大型报告较少,成功的预后因素仍不明确。
纳入1996年至2014年接受RVF手术的所有患者。
79例患者中,34例(43%)因克罗恩病出现RVF,25例(32%)为术后发生,7例(9%)为产科原因,4例(5%)为放射性直肠炎,9例(11%)为其他原因。共进行了286次手术(132次伴有造口,46%),其中217次为保守手术(76%)[挂线引流(n = 59;21%)、经阴道手术(n = 49,17%)或直肠推进皮瓣手术(n = 46;16%)、仅行转流造口术(n = 27;9%)、封堵术(n = 15;5%)、胶水封堵术(n = 13;5%)或其他手术(n = 8,3%)];69次为大型手术(24%)[股薄肌置入术(n = 32;11%)、结肠肛管或结肠直肠吻合术(n = 19;7%),其中11次为延迟吻合加结肠拖出术、生物补片置入术(n = 9,3%)和腹会阴联合切除术(n = 9;3%)]。平均随访33个月后,79例患者中有57例(72%)总体成功。基于手术的多因素分析确定大型手术[比值比(OR):6.4(2.9 - 14.2);P < 0.001]、转流造口术[OR:3.5(1.4 - 8.7);P = 0.009]、诊断与首次手术间隔小于9个月[OR:2.3(1.1 - 5.3);P = 0.046]以及在本机构进行首次手术[OR:3.2(1.5 - 6.9);P = 0.003]为成功的独立因素。
我们的研究表明,积极的RVF手术治疗,包括早期使用临时造口以及在先前局部治疗失败时采用大型手术,可取得较高的成功率。