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吸入性损伤诊断方法与患者预后分析

An Analysis of Inhalation Injury Diagnostic Methods and Patient Outcomes.

作者信息

Ching Jessica A, Ching Yiu-Hei, Shivers Steven C, Karlnoski Rachel A, Payne Wyatt G, Smith David J

机构信息

From the *Division of Plastic Surgery, †Department of Surgery, Morsani College of Medicine, University of South Florida Health, Tampa; and ‡Institute for Tissue Regeneration, Bay Pines VA Healthcare System, Florida.

出版信息

J Burn Care Res. 2016 Jan-Feb;37(1):e27-32. doi: 10.1097/BCR.0000000000000313.

Abstract

The purpose of this study was to compare patient outcomes according to the method of diagnosing burn inhalation injury. After approval from the American Burn Association, the National Burn Repository Dataset Version 8.0 was queried for patients with a diagnosis of burn inhalation injury. Subgroups were analyzed by diagnostic method as defined by the National Burn Repository. All diagnostic methods listed for each patient were included, comparing mortality, hospital days, intensive care unit (ICU) days, and ventilator days (VDs). Z-tests, t-tests, and linear regression were used with a statistical significance of P value of less than .05. The database query yielded 9775 patients diagnosed with inhalation injury. The greatest increase in mortality was associated with diagnosis by bronchoscopy or carbon monoxide poisoning. A relative increase in hospital days was noted with diagnosis by bronchoscopy (9 days) or history (2 days). A relative increase in ICU days was associated with diagnosis according to bronchoscopy (8 days), clinical findings (2 days), or history (2 days). A relative increase in VDs was associated with diagnosis by bronchoscopy (6 days) or carbon monoxide poisoning (3 days). The combination of diagnosis by bronchoscopy and clinical findings increased the relative difference across all comparison measures. The combination of diagnosis by bronchoscopy and carbon monoxide poisoning exhibited decreased relative differences when compared with bronchoscopy alone. Diagnosis by laryngoscopy showed no mortality or association with poor outcomes. Bronchoscopic evidence of inhalation injury proved most useful, predicting increased mortality, hospital, ICU, and VDs. A combined diagnosis determined by clinical findings and bronchoscopy should be considered for clinical practice.

摘要

本研究的目的是根据烧伤吸入性损伤的诊断方法比较患者的治疗结果。经美国烧伤协会批准,查询了国家烧伤资料库数据集第8.0版中诊断为烧伤吸入性损伤的患者。根据国家烧伤资料库定义的诊断方法对亚组进行分析。纳入每位患者列出的所有诊断方法,比较死亡率、住院天数、重症监护病房(ICU)天数和呼吸机使用天数(VDs)。使用Z检验、t检验和线性回归,P值小于0.05具有统计学意义。数据库查询得到9775例诊断为吸入性损伤的患者。死亡率的最大增加与支气管镜检查或一氧化碳中毒诊断相关。支气管镜检查诊断(9天)或病史诊断(2天)的住院天数有相对增加。ICU天数的相对增加与支气管镜检查诊断(8天)、临床检查结果诊断(2天)或病史诊断(2天)相关。VDs的相对增加与支气管镜检查诊断(6天)或一氧化碳中毒诊断(3天)相关。支气管镜检查诊断和临床检查结果的联合使用增加了所有比较指标的相对差异。与单独支气管镜检查相比,支气管镜检查诊断和一氧化碳中毒诊断的联合使用显示相对差异降低。喉镜检查诊断未显示死亡率或与不良预后相关。支气管镜检查发现的吸入性损伤证据被证明最有用,可预测死亡率、住院天数、ICU天数和VDs增加。临床实践中应考虑结合临床检查结果和支气管镜检查进行综合诊断。

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