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成人脑出血的评估与管理

The Evaluation and Management of Adult Intracerebral Hemorrhage.

作者信息

Cai Xuemei, Rosand Jonathan

机构信息

Division of Neurocritical Care and Emergency Neurology, Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston, Massachusetts.

Division of Neurocritical Care and Emergency Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts.

出版信息

Semin Neurol. 2015 Dec;35(6):638-45. doi: 10.1055/s-0035-1564687. Epub 2015 Nov 23.

Abstract

Intracerebral hemorrhage (ICH) is the most disabling and deadly form of stroke. Although mortality remains high, new data suggest that outcomes can be improved with standardized medical care. In this review, the authors outline the most up-to-date knowledge, including the results of the latest phase III clinical trials on the specialized care needed to treat patients with ICH. They provide an overview on how to achieve rapid diagnosis and the initial steps of intervention to reduce hematoma volume or prevent expansion by modifying potentially treatable conditions, such as underlying vascular etiologies, blood pressure control, and coagulopathies. Grading scales can help identify patients at risk for hematoma expansion and functional disabilities and guide clinical decision making. Other medical management topics important to recovery and prevention of secondary brain injury include seizure prevention and treatment, glycemic control, temperature control, and deep venous thrombosis prophylaxis and treatment. Treatment options in surgery are also possible in select patients; there are emerging studies regarding minimally invasive surgery for the management of ICH. These aggressive therapies are essential to lower the morbidity and mortality of patients presenting with ICH.

摘要

脑出血(ICH)是最具致残性和致命性的中风形式。尽管死亡率仍然很高,但新数据表明,标准化医疗护理可改善预后。在本综述中,作者概述了最新知识,包括关于治疗脑出血患者所需专门护理的最新III期临床试验结果。他们概述了如何实现快速诊断以及干预的初始步骤,以通过改善潜在可治疗状况(如潜在血管病因、血压控制和凝血病)来减少血肿体积或防止血肿扩大。分级量表有助于识别有血肿扩大和功能残疾风险的患者,并指导临床决策。对恢复和预防继发性脑损伤重要的其他医疗管理主题包括癫痫预防和治疗、血糖控制、体温控制以及深静脉血栓形成的预防和治疗。对于部分患者,手术治疗也是一种选择;关于脑出血管理的微创手术有一些新出现的研究。这些积极的治疗对于降低脑出血患者的发病率和死亡率至关重要。

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