一例服用舍曲林的经前烦躁障碍患者的低血糖发作

Hypoglycemic episodes in a case of Prementrual Dysphoric Disorder on sertraline.

作者信息

Santra Dhali Ranjita, Banerjee Prithwijit, Munshi Santanu, Chaudhuri Patralekha Ray

机构信息

Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.

Department of Pharmacology, Sagar Dutta Medical College, Kolkata, West Bengal, India.

出版信息

Indian J Pharmacol. 2015 Sep-Oct;47(5):567-8. doi: 10.4103/0253-7613.165193.

DOI:10.4103/0253-7613.165193

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4621684/

Abstract

Sertraline is a selective serotonin reuptake inhibitor. It has been shown to blunt postprandial hyperglycemia in rats and to potentiate the hypoglycemic effects of sulfonylurea agents in humans. Here, we report a case of a 33-year-old nondiabetic patient with no history of glucose intolerance, who experienced multiple episodes of hypoglycemia that resolved after discontinuation of the drug. Healthcare professionals should consider sertraline among the possible causes of hypoglycemia occurring in patients receiving antidepressants.

摘要

舍曲林是一种选择性5-羟色胺再摄取抑制剂。研究表明，它可抑制大鼠餐后高血糖，并增强磺脲类药物对人体的降血糖作用。在此，我们报告一例33岁非糖尿病患者，该患者无葡萄糖不耐受病史，却经历了多次低血糖发作，停药后低血糖症状缓解。医疗保健专业人员应将舍曲林视为接受抗抑郁药治疗的患者发生低血糖的可能原因之一。

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The association between antidepressant use and disturbances in glucose homeostasis: evidence from spontaneous reports.抗抑郁药使用与葡萄糖稳态紊乱之间的关联：来自自发报告的证据。

Eur J Clin Pharmacol. 2008 May;64(5):531-8. doi: 10.1007/s00228-007-0441-y. Epub 2008 Jan 15.

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Sertraline-induced hypoglycemia.舍曲林诱发的低血糖症。

Ann Pharmacother. 2001 Nov;35(11):1371-4. doi: 10.1345/aph.1Z431.

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