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背侧加层尿道成形术治疗膜性尿道狭窄:尿控和勃起功能结果。

Dorsal Onlay Urethroplasty for Membranous Urethral Strictures: Urinary and Erectile Functional Outcomes.

机构信息

State University of New York Upstate Medical University, Department of Urology, Syracuse, New York; State University of New York Upstate Medical University, Department of Pathology (TC, SL), Syracuse, New York.

State University of New York Upstate Medical University, Department of Urology, Syracuse, New York; State University of New York Upstate Medical University, Department of Pathology (TC, SL), Syracuse, New York.

出版信息

J Urol. 2016 May;195(5):1501-1507. doi: 10.1016/j.juro.2015.11.028. Epub 2015 Nov 19.

Abstract

PURPOSE

We evaluated urinary and erectile functional outcomes after dorsal onlay urethroplasty for bulbomembranous urethral strictures. Our aim was to understand the functional implications of dissection of the posterior urethra.

MATERIALS AND METHODS

We report on men who underwent membranous urethral stricture repair by buccal mucosal graft dorsal onlay substitution urethroplasty. Continence and erectile function were assessed preoperatively and postoperatively. Tissue routinely excised from the intercrural space during dissection of the dorsal aspect of the membranous urethra was evaluated for scar, striated muscle and nerves.

RESULTS

A total of 16 consecutive men with a mean age of 48.3 years (range 26 to 72) who had strictures with a mean length of 56 mm (range 15 to 170) involving the membranous urethra were included in analysis. Of the 16 men 15 were continent preoperatively and remained continent postoperatively. Three of 10 men (30%) with a preoperative SHIM (Sexual Health Inventory for Men) score of 17 to 25 had a decrease after urethroplasty. All 16 men had an improved maximum urinary flow rate with a mean improvement of 22 ml per second. I-PSS (International Prostate Symptom Score) improved from a median of 23 to 4 postoperatively with a median bother score improvement of 5 to 0. Histopathological assessment identified striated muscle and nerves in 6 (46%) and 9 (69%) of 13 specimens. Overall nerves and muscle comprised an average of less than 15% of the specimen.

CONCLUSIONS

The dorsal onlay technique with a buccal mucosal graft for membranous urethral stricture repair does not compromise continence or erectile function in most patients. Dissection at the level of the membranous urethra should be limited because striated muscle and cavernous nerves are present.

摘要

目的

我们评估了后尿道瓣状成形术治疗球膜部尿道狭窄的尿控和勃起功能。我们的目的是了解后尿道解剖的功能意义。

材料和方法

我们报告了 16 例接受颊黏膜移植物后尿道瓣状替代成形术治疗膜部尿道狭窄的男性患者。评估术前和术后的尿控和勃起功能。对在膜部尿道背侧解剖过程中从阴茎海绵体间间隙常规切除的组织进行瘢痕、横纹肌和神经评估。

结果

共纳入 16 例连续男性患者,平均年龄 48.3 岁(26 至 72 岁),平均狭窄长度 56mm(15 至 170mm),累及膜部尿道。16 例患者中有 15 例术前有尿控,术后仍有尿控。10 例术前 SHIM(男性性健康问卷)评分为 17 至 25 分的患者中有 3 例术后评分下降。所有 16 例患者最大尿流率均有改善,平均增加 22ml/s。国际前列腺症状评分(I-PSS)从术后中位数 23 分降至 4 分,术后中位数困扰评分从 5 分降至 0 分。组织病理学评估在 13 例标本中发现 6 例(46%)和 9 例(69%)有横纹肌和神经。总体而言,神经和肌肉占标本的比例不足 15%。

结论

对于大多数患者来说,采用颊黏膜移植物的后尿道瓣状成形术治疗膜部尿道狭窄不会影响尿控和勃起功能。应限制在膜部尿道水平进行解剖,因为有横纹肌和海绵体神经存在。

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