头孢洛林对人工关节感染患者分离葡萄球菌的体外活性
In vitro activity of ceftaroline against staphylococci from prosthetic joint infection.
作者信息
Park Kyung-Hwa, Greenwood-Quaintance Kerryl E, Patel Robin
机构信息
Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905; Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, South Korea.
Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905.
出版信息
Diagn Microbiol Infect Dis. 2016 Feb;84(2):141-3. doi: 10.1016/j.diagmicrobio.2015.10.012. Epub 2015 Oct 21.
We tested the in vitro activity of ceftaroline by Etest against staphylococci recovered from patients with prosthetic joint infection, including 97 Staphylococcus aureus isolates (36%, oxacillin resistant) and 74 Staphylococcus epidermidis isolates (74%, oxacillin resistant). Ceftaroline inhibited all staphylococci at ≤0.5 μg/mL. The ceftaroline MIC(90/50) values for methicillin-susceptible S. aureus, methicillin-susceptible S. epidermidis, methicillin-resistant S. aureus, and methicillin-resistant S. epidermidis were 0.19/0.125, 0.094/0.047, 0.5/0.38, and 0.38/0.19 μg/mL, respectively. Based on these in vitro findings, ceftaroline should be further evaluated as a potential therapeutic option for the treatment of prosthetic joint infection caused by methicillin-susceptible and methicillin-resistant S. aureus and S. epidermidis.
我们采用Etest法检测了头孢洛林对从人工关节感染患者中分离出的葡萄球菌的体外活性，其中包括97株金黄色葡萄球菌分离株（36%对苯唑西林耐药）和74株表皮葡萄球菌分离株（74%对苯唑西林耐药）。头孢洛林对所有葡萄球菌的抑菌浓度均≤0.5μg/mL。对甲氧西林敏感金黄色葡萄球菌、甲氧西林敏感表皮葡萄球菌、甲氧西林耐药金黄色葡萄球菌和甲氧西林耐药表皮葡萄球菌，头孢洛林的MIC(90/50)值分别为0.19/0.125、0.094/0.047、0.5/0.38和0.38/0.19μg/mL。基于这些体外研究结果，头孢洛林应作为治疗由甲氧西林敏感和耐药的金黄色葡萄球菌及表皮葡萄球菌引起的人工关节感染的潜在治疗选择作进一步评估。
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