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应对坚果诱发的过敏反应:挑战与解决方案。

Managing nut-induced anaphylaxis: challenges and solutions.

作者信息

Lomas Jeanne M, Järvinen Kirsi M

机构信息

Division of Pediatric Allergy and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

出版信息

J Asthma Allergy. 2015 Oct 29;8:115-23. doi: 10.2147/JAA.S89121. eCollection 2015.

Abstract

The prevalence of peanut and tree nut allergy in the USA has increased, especially in the pediatric population. Nut allergy remains the leading cause of fatal anaphylactic reactions. Management of anaphylaxis includes not only treatment of symptoms during a reaction, but strict dietary avoidance and education on potential situations, which may place the patient at high risk for accidental exposure. Cross-reactivity between various nuts along with various cross-contamination sources should be discussed with all nut-allergic individuals. Exciting research continues to emerge on other potential treatments for patients allergic to nuts, including allergen immunotherapy. Results of such interventions have been encouraging, though further studies are needed regarding safety and long-term outcomes before these can be applied to clinical practice.

摘要

在美国,花生和坚果过敏的患病率有所上升,尤其是在儿童群体中。坚果过敏仍然是致命过敏反应的主要原因。过敏反应的管理不仅包括在反应期间对症状的治疗,还包括严格的饮食回避以及对可能使患者面临意外接触高风险的潜在情况的教育。应与所有坚果过敏个体讨论各种坚果之间的交叉反应以及各种交叉污染来源。关于坚果过敏患者的其他潜在治疗方法,包括过敏原免疫疗法,令人兴奋的研究不断涌现。这些干预措施的结果令人鼓舞,不过在将其应用于临床实践之前,还需要就安全性和长期结果进行进一步研究。

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