In search for novel strategies towards neuroprotection and neuroregeneration: is PPARα a promising therapeutic target?
作者信息
Moreno Sandra, Cerù Maria Paola
机构信息
Department of Science-LIME, University Roma Tre, Rome, Italy.
Department of Science-LIME, University Roma Tre, Rome, Italy ; Department of Life, Health and Environmental Sciences, University of L'Aquila, Coppito (AQ), Italy.
出版信息
Neural Regen Res. 2015 Sep;10(9):1409-12. doi: 10.4103/1673-5374.165313.
Abstract
摘要
相似文献
1
In search for novel strategies towards neuroprotection and neuroregeneration: is PPARα a promising therapeutic target?
Neural Regen Res. 2015 Sep;10(9):1409-12. doi: 10.4103/1673-5374.165313.
2
Neurodegeneration, Neuroregeneration, and Neuroprotection in Psychiatric Disorders.
Mod Trends Pharmacopsychiatry. 2017;31:107-123. doi: 10.1159/000470811. Epub 2017 Jul 24.
3
New perspectives on molecular and cellular mechanisms of neuroprotection and neuroregeneration: part I.
Expert Rev Neurother. 2010 Jul;10(7):1039-43. doi: 10.1586/ern.10.79.
4
New perspectives on molecular and cellular mechanisms of neuroprotection and neuroregeneration: part II.
Expert Rev Neurother. 2010 Aug;10(8):1253-7. doi: 10.1586/ern.10.78.
5
How does zebrafish support new strategies for neuroprotection and neuroregeneration in hypoxia-related diseases?
Neural Regen Res. 2016 Jul;11(7):1069-70. doi: 10.4103/1673-5374.187030.
6
Physiological role of peroxisome proliferator-activated receptors type α on dopamine systems.
CNS Neurol Disord Drug Targets. 2013 Feb 1;12(1):70-7. doi: 10.2174/1871527311312010012.
7
Collagen for brain repair: therapeutic perspectives.
Neural Regen Res. 2018 Apr;13(4):595-598. doi: 10.4103/1673-5374.230273.
8
Novel therapeutic strategies using nanodrug delivery, stem cells and combination therapy for CNS trauma and neurodegenerative disorders.
Expert Rev Neurother. 2013 Oct;13(10):1085-8. doi: 10.1586/14737175.2013.836297. Epub 2013 Oct 3.
9
6th Global College of Neuroprotection and Neuroregeneration, annual meeting.
Expert Rev Neurother. 2009 Jul;9(7):941-7. doi: 10.1586/ern.09.58.
10
Nucleotides in neuroregeneration and neuroprotection.
Neuropharmacology. 2016 May;104:243-54. doi: 10.1016/j.neuropharm.2015.09.002. Epub 2015 Sep 8.
引用本文的文献
1
Role of peroxisome proliferator-activated receptor alpha in neurodegenerative diseases and other neurological disorders: Clinical application prospects.
Neural Regen Res. 2025 Jun 19. doi: 10.4103/NRR.NRR-D-24-01371.
2
Recent advancements in the understanding of the alterations in mitochondrial biogenesis in Alzheimer's disease.
Mol Biol Rep. 2025 Jan 29;52(1):173. doi: 10.1007/s11033-025-10297-6.
3
Cannabidiol abrogates cue-induced anxiety associated with normalization of mitochondria-specific transcripts and linoleic acid in the nucleus accumbens shell.
Mol Psychiatry. 2025 Jun;30(6):2718-2728. doi: 10.1038/s41380-024-02881-2. Epub 2025 Jan 15.
4
Fenofibrate Decreases Ethanol-Induced Neuroinflammation and Oxidative Stress and Reduces Alcohol Relapse in Rats by a PPAR-α-Dependent Mechanism.
Antioxidants (Basel). 2023 Sep 13;12(9):1758. doi: 10.3390/antiox12091758.
5
Co-Ultramicronized Palmitoylethanolamide/Luteolin Restores Oligodendrocyte Homeostasis via Peroxisome Proliferator-Activated Receptor-α in an In Vitro Model of Alzheimer's Disease.
Biomedicines. 2022 May 26;10(6):1236. doi: 10.3390/biomedicines10061236.
6
Satellite Glial Cells in Pain Research: A Targeted Viewpoint of Potential and Future Directions.
Front Pain Res (Lausanne). 2021 Mar 10;2:646068. doi: 10.3389/fpain.2021.646068. eCollection 2021.
7
Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair.
Elife. 2021 Sep 29;10:e68457. doi: 10.7554/eLife.68457.
8
Satellite glial cells promote regenerative growth in sensory neurons.
Nat Commun. 2020 Sep 29;11(1):4891. doi: 10.1038/s41467-020-18642-y.
9
Innovative Therapies and Nanomedicine Applications for the Treatment of Alzheimer's Disease: A State-of-the-Art (2017-2020).
Int J Nanomedicine. 2020 Aug 14;15:6113-6135. doi: 10.2147/IJN.S231480. eCollection 2020.
10
The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders.
Neurochem Res. 2020 May;45(5):972-988. doi: 10.1007/s11064-020-02993-5. Epub 2020 Mar 13.
本文引用的文献
1
Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease.
Oxid Med Cell Longev. 2015;2015:967203. doi: 10.1155/2015/967203. Epub 2015 Apr 20.
2
Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders.
J Biol Chem. 2015 Apr 17;290(16):10309-24. doi: 10.1074/jbc.M114.610659. Epub 2015 Mar 6.
3
Fenofibrate reduces amyloidogenic processing of APP in APP/PS1 transgenic mice via PPAR-α/PI3-K pathway.
Int J Dev Neurosci. 2014 Nov;38:223-31. doi: 10.1016/j.ijdevneu.2014.10.004. Epub 2014 Oct 30.
4
Nutrient-sensing nuclear receptors coordinate autophagy.
Nature. 2014 Dec 4;516(7529):112-5. doi: 10.1038/nature13961. Epub 2014 Nov 12.
5
Stem cells in neuroinjury and neurodegenerative disorders: challenges and future neurotherapeutic prospects.
Neural Regen Res. 2014 May 1;9(9):901-6. doi: 10.4103/1673-5374.133129.
6
Role of Glitazars in atherogenic dyslipidemia and diabetes: Two birds with one stone?
Indian J Endocrinol Metab. 2014 May;18(3):283-7. doi: 10.4103/2230-8210.131134.
7
Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARα) and its lipid ligands.
Curr Med Chem. 2014;21(24):2803-21. doi: 10.2174/0929867321666140303143455.
8
PPAR-α agonist fenofibrate protects against the damaging effects of MPTP in a rat model of Parkinson's disease.
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Aug 4;53:35-44. doi: 10.1016/j.pnpbp.2014.02.009. Epub 2014 Mar 1.
9
Effects of the PPAR-α agonist fenofibrate on acute and short-term consequences of brain ischemia.
J Cereb Blood Flow Metab. 2014 Mar;34(3):542-51. doi: 10.1038/jcbfm.2013.233. Epub 2014 Jan 8.
10
Preclinical models of stroke in aged animals with or without comorbidities: role of neuroinflammation.
Biogerontology. 2013 Dec;14(6):651-62. doi: 10.1007/s10522-013-9465-0. Epub 2013 Sep 22.
Zotero 插件