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血清素7受体变体与日本精神分裂症患者对第二代抗精神病药物的反应无关。

Serotonin 7 Receptor Variants Are Not Associated with Response to Second-Generation Antipsychotics in Japanese Schizophrenia Patients.

作者信息

Takekita Yoshiteru, Fabbri Chiara, Kato Masaki, Nonen Shinpei, Sakai Shiho, Sunada Naotaka, Koshikawa Yosuke, Wakeno Masataka, Okugawa Gaku, Kinoshita Toshihiko, Serretti Alessandro

机构信息

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

出版信息

Neuropsychobiology. 2015;72(2):118-25. doi: 10.1159/000441629. Epub 2015 Nov 27.

Abstract

BACKGROUND

Individual differences in serotonin 7 receptor (5-HT7R) may result in variable response to antipsychotics with 5-HT7R antagonism. This study investigated the relationship between single nucleotide polymorphisms (SNPs) in the 5-HT7R gene (HTR7) and the efficacy of second-generation antipsychotic drugs with a high affinity for this receptor in Japanese schizophrenia.

METHODS

Perospirone or aripiprazole was administered to 100 patients with schizophrenia in a randomized controlled study. All patients were genotyped for three candidate SNPs (rs12412496, rs7916403, and rs1935349). Patient improvement on the Positive and Negative Syndrome Scale (PANSS) total score at 12 weeks was assessed as the primary outcome. PANSS 5-factor scores were investigated as the secondary outcome.

RESULTS

Improvement on the PANSS total score and genetic polymorphisms showed no correlation. The rs12412496-rs7916403-rs1935349 A-T-A haplotype was correlated with worse improvement in the cognition score (haplotype frequency: 0.285, p = 0.046, permuted p = 0.043).

CONCLUSION

Our results show that HTR7 variants are not related to the overall improvement in schizophrenia symptoms.

摘要

背景

血清素7受体(5-HT7R)的个体差异可能导致对具有5-HT7R拮抗作用的抗精神病药物产生不同反应。本研究调查了5-HT7R基因(HTR7)中的单核苷酸多态性(SNP)与第二代抗精神病药物对该受体具有高亲和力在日本精神分裂症患者中的疗效之间的关系。

方法

在一项随机对照研究中,对100例精神分裂症患者给予哌罗匹隆或阿立哌唑。所有患者均对三个候选SNP(rs12412496、rs7916403和rs1935349)进行基因分型。以12周时阳性和阴性症状量表(PANSS)总分的改善情况作为主要结局进行评估。以PANSS 5因子得分作为次要结局进行研究。

结果

PANSS总分的改善与基因多态性之间无相关性。rs12412496-rs7916403-rs1935349 A-T-A单倍型与认知得分的较差改善相关(单倍型频率:0.285,p = 0.046,置换p = 0.043)。

结论

我们的结果表明,HTR7变异与精神分裂症症状的总体改善无关。

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