Tartara A, Manni R, Galimberti C A, Mumford J P, Iudice A, Perucca E
Institute of Neurology C. Mondino, University of Pavia, Italy.
J Neurol Neurosurg Psychiatry. 1989 Apr;52(4):467-71. doi: 10.1136/jnnp.52.4.467.
Twenty-five adult epileptic patients who had shown a satisfactory clinical response to add-on vigabatrin under placebo-controlled conditions continued on long-term treatment for up to 47 months (median 22 months). The initially favourable therapeutic response was generally maintained throughout the observation period with an overall good clinical tolerance. No evidence of neurotoxicity was detected by multimodal evoked potentials monitoring.
25名成年癫痫患者在安慰剂对照条件下对加用氨己烯酸表现出令人满意的临床反应,他们继续接受长达47个月(中位数为22个月)的长期治疗。在整个观察期内,最初良好的治疗反应总体上得以维持,临床耐受性良好。多模式诱发电位监测未发现神经毒性迹象。