股骨头缺血性坏死中交感神经纤维的改变。
Alterations of sympathetic nerve fibers in avascular necrosis of femoral head.
作者信息
Li Deqiang, Liu Peilai, Zhang Yuankai, Li Ming
机构信息
Department of Orthopedics, Qilu Hospital of Shandong University China.
出版信息
Int J Clin Exp Pathol. 2015 Sep 1;8(9):10947-52. eCollection 2015.
OBJECTIVES
Avascular necrosis of the femoral head (ANFH) was mainly due to alterations of bone vascularity. And noradrenaline (NA), as the neurotransmitter of the sympathetic nervous system (SNS), leads to the vasoconstriction by activating its α-Receptor. This study was to explore the nerve fiber density of the femoral head in the rabbit model of ANFH.
METHODS
Twenty New Zealand white rabbits were used in this study. The rabbit model of ANFH was established by the injection of methylprednisolone acetate. The nerve fiber density and distribution in the femoral head was determined using an Olympus BH2 microscope.
RESULTS
Significant fewer sympathetic nerve fibers was found in the ANFH intertrochanteric bone samples (P = 0.036) with osteonecrosis. The number of sympathetic nerve fibers was compared between the two groups. And less sympathetic nerve fibers were found in later stage ANFH samples in comparison with those of early stages.
CONCLUSIONS
ANFH might be preceded by an inflammatory reaction, and an inflammatory response might lead to arthritic changes in tissue samples, which in turn reduces the number of sympathetic nerve fibers.
目的
股骨头缺血性坏死（ANFH）主要归因于骨血管的改变。去甲肾上腺素（NA）作为交感神经系统（SNS）的神经递质，通过激活其α受体导致血管收缩。本研究旨在探讨ANFH兔模型中股骨头的神经纤维密度。
方法
本研究使用了20只新西兰白兔。通过注射醋酸甲基泼尼松龙建立ANFH兔模型。使用奥林巴斯BH2显微镜测定股骨头的神经纤维密度和分布。
结果
在伴有骨坏死的ANFH转子间骨样本中发现交感神经纤维明显减少（P = 0.036）。比较了两组交感神经纤维的数量。与早期相比，晚期ANFH样本中的交感神经纤维较少。
结论
ANFH可能先于炎症反应出现，炎症反应可能导致组织样本发生关节炎变化，进而减少交感神经纤维的数量。
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