文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Sawada H, Hara A, Nakagawa M, Tsukada F, Ohmura M, Matsuura K

Department of Biochemistry, Gifu Pharmaceutical University, Japan.

Int J Biochem. 1989;21(4):367-75. doi: 10.1016/0020-711x(89)90360-1.

Five multiple forms of dihydrodiol dehydrogenase (EC 1.3.1.20) with similar molecular weights of around 35,000 were purified from hamster liver cytosol. 2. All the enzymes oxidized trans-dihydrodiols of benzene and naphthalene and reduced various carbonyl compounds, but showed clear differences in specificities for other alcohols and cofactors, and in inhibitor sensitivity. 3. Two NADP+-dependent enzymes were immunologically identified with aldehyde reductase (EC 1.1.1.2) and 3 alpha-hydroxytsteroid dehydrogenase (EC 1.1.1.50). 4. The other enzymes with dual cofactor specificity oxidized xenobiotic alicyclic alcohols, and one of them was active on 3 alpha- and 17 beta-hydroxysteroids with NAD+ as a preferable cofactor.

从仓鼠肝细胞溶胶中纯化出五种分子量相似、约为35000的二氢二醇脱氢酶（EC 1.3.1.20）多种形式。2. 所有这些酶都能氧化苯和萘的反式二氢二醇并还原各种羰基化合物，但在对其他醇类和辅因子的特异性以及抑制剂敏感性方面存在明显差异。3. 两种依赖NADP⁺的酶经免疫鉴定为醛还原酶（EC 1.1.1.2）和3α-羟基类固醇脱氢酶（EC 1.1.1.50）。4. 其他具有双辅因子特异性的酶能氧化外源性脂环醇，其中一种对3α-和17β-羟基类固醇有活性，以NAD⁺作为更合适的辅因子。

Sawada H, Hara A, Nakagawa M, Tsukada F, Ohmura M, Matsuura K

Department of Biochemistry, Gifu Pharmaceutical University, Japan.

Int J Biochem. 1989;21(4):367-75. doi: 10.1016/0020-711x(89)90360-1.

Five multiple forms of dihydrodiol dehydrogenase (EC 1.3.1.20) with similar molecular weights of around 35,000 were purified from hamster liver cytosol. 2. All the enzymes oxidized trans-dihydrodiols of benzene and naphthalene and reduced various carbonyl compounds, but showed clear differences in specificities for other alcohols and cofactors, and in inhibitor sensitivity. 3. Two NADP+-dependent enzymes were immunologically identified with aldehyde reductase (EC 1.1.1.2) and 3 alpha-hydroxytsteroid dehydrogenase (EC 1.1.1.50). 4. The other enzymes with dual cofactor specificity oxidized xenobiotic alicyclic alcohols, and one of them was active on 3 alpha- and 17 beta-hydroxysteroids with NAD+ as a preferable cofactor.

从仓鼠肝细胞溶胶中纯化出五种分子量相似、约为35000的二氢二醇脱氢酶（EC 1.3.1.20）多种形式。2. 所有这些酶都能氧化苯和萘的反式二氢二醇并还原各种羰基化合物，但在对其他醇类和辅因子的特异性以及抑制剂敏感性方面存在明显差异。3. 两种依赖NADP⁺的酶经免疫鉴定为醛还原酶（EC 1.1.1.2）和3α-羟基类固醇脱氢酶（EC 1.1.1.50）。4. 其他具有双辅因子特异性的酶能氧化外源性脂环醇，其中一种对3α-和17β-羟基类固醇有活性，以NAD⁺作为更合适的辅因子。