肾母细胞瘤过度表达（NOV）在结直肠癌患者中的表达的临床意义
Clinical Significance of Expression of Nephroblastoma Overexpressed (NOV) in Patients with Colorectal Cancer.
作者信息
Ueda Masami, Iguchi Tomohiro, Komatsu Hisateru, Kidogami Shinya, Hu Qingjiang, Sato Kuniaki, Ogawa Yushi, Nambara Sho, Saito Tomoko, Sakimura Shotaro, Hirata Hidenari, Uchi Ryutaro, Shinden Yoshiaki, Eguchi Hidetoshi, Ito Shuhei, Masuda Takaaki, Yamamoto Hirofumi, Doki Yuichiro, Mori Masaki, Mimori Koshi
机构信息
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
出版信息
Anticancer Res. 2015 Dec;35(12):6591-7.
BACKGROUND
The nephroblastoma overexpressed (NOV) gene, which belongs to the cysteine-rich, angiogenic inducer 61/connective tissue growth factor/nephroblastoma overexpressed (CCN) family, is located in the 8q24 region and promotes migration and invasiveness in several types of malignancies. We explored the clinical significance of NOV expression in colorectal cancer (CRC).
MATERIALS AND METHODS
NOV expression in CRC specimens and CRC cell lines were evaluated. The association between the clinicopathlogical factors and NOV mRNA expression of tumor tissues was assessed in 126 patients with CRC. We assessed the relationships between NOV expression and overall survival in public databases. We performed overexpression experiments in vitro.
RESULTS
CRC specimens and CRC cell lines showed high NOV expression. High NOV mRNA expression was correlated with poorer overall survival and higher Union for International Cancer Control (UICC) T factor. In public databases, high NOV expression was associated with poorer prognoses. Overexpression of NOV promoted invasiveness of CRC cells.
CONCLUSION
NOV may be an indicator of poor prognosis and a therapeutic target in CRC.
背景
肾母细胞瘤过度表达（NOV）基因属于富含半胱氨酸的血管生成诱导因子61/结缔组织生长因子/肾母细胞瘤过度表达（CCN）家族，位于8q24区域，在多种恶性肿瘤中促进迁移和侵袭。我们探讨了NOV表达在结直肠癌（CRC）中的临床意义。
材料与方法
评估CRC标本和CRC细胞系中NOV的表达。在126例CRC患者中评估肿瘤组织的临床病理因素与NOV mRNA表达之间的关联。我们在公共数据库中评估了NOV表达与总生存期之间的关系。我们进行了体外过表达实验。
结果
CRC标本和CRC细胞系显示出较高的NOV表达。高NOV mRNA表达与较差的总生存期以及较高的国际癌症控制联盟（UICC）T因子相关。在公共数据库中，高NOV表达与较差的预后相关。NOV的过表达促进了CRC细胞的侵袭。
结论
NOV可能是CRC预后不良的指标和治疗靶点。
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