[中性粒细胞明胶酶相关脂质运载蛋白与代谢综合征关系的研究进展]

[Progress in research on the relationship between NGAL and metabolic syndrome].

作者信息

Li Bei, Huang Jin

机构信息

Department of Xiangya Nursing, Central South University, Changsha 410013, China.

Department of Nursing, Second Xiangya Hospital, Central South University, Changsha 410011, China.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 Nov;40(11):1264-9. doi: 10.11817/j.issn.1672-7347.2015.11.017.

DOI:10.11817/j.issn.1672-7347.2015.11.017

PMID:26643433

Abstract

Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin family. As a novel adipokine, it widely presents in the tissues under the condition of metabolic disorders. More and more studies suggest that NGAL might be a marker for a variety of diseases associated with lipid metabolism. It is likely that NGAL plays an important role in obese-inflammation-induced metabolic syndrome,insulin resistance, glucose and lipid metabolism, endothelial dysfunction and atherosclerosis pathway.

摘要

中性粒细胞明胶酶相关脂质运载蛋白（NGAL）是脂质运载蛋白家族的一员。作为一种新型脂肪因子，它在代谢紊乱情况下广泛存在于组织中。越来越多的研究表明，NGAL可能是多种与脂质代谢相关疾病的标志物。NGAL很可能在肥胖炎症诱导的代谢综合征、胰岛素抵抗、糖脂代谢、内皮功能障碍和动脉粥样硬化途径中发挥重要作用。