[外泌体衍生的微小RNA在疾病诊断与治疗中作用的研究进展]
[Progress in study on the role of exosome-derived microRNA in diagnosis and treatment of diseases].
作者信息
Tang Hui, Wu Haishan, Yang Yi, Zhao Jingping, Chen Jindong
机构信息
Mental Health Institute of the Second Xiangya Hospital, Central South University; The China National Clinical Research Center for Mental Health Disorders; National Technology Institute of Psychiatry; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha 410011, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 Nov;40(11):1270-5. doi: 10.11817/j.issn.1672-7347.2015.11.018.
Exosome is a kind of biological membrane structure at nanometer level. It is secreted by various cells in the body and widely distributed in most body fluids, such as saliva, blood, and milk. Biological active substances, including mRNAs, microRNAs, cytokines, and transcription factor, have been identified in the exosomes. MiRNAs are short and non-coding RNAs that modulate gene expression at the posttranscriptional level. MiRNAs extensively involves in henogenesis, cell proliferation and apoptosis. With various biological functions, exosome-derived miRNAs can not only be served as biomarkers to diagnose tumor, neurological diseases and mental disorders, but also possess potential as therapeutic targets.
外泌体是一种纳米级的生物膜结构。它由体内各种细胞分泌，广泛分布于大多数体液中，如唾液、血液和乳汁。在外泌体中已鉴定出包括mRNA、微小RNA、细胞因子和转录因子在内的生物活性物质。微小RNA是短的非编码RNA，可在转录后水平调节基因表达。微小RNA广泛参与胚胎发育、细胞增殖和凋亡。具有多种生物学功能的外泌体衍生微小RNA不仅可作为诊断肿瘤、神经疾病和精神障碍的生物标志物，还具有作为治疗靶点的潜力。
Zotero 插件