Adeyeye A A, Ate I U, Lawal A I, Adamu S
Department of Theriogenology and Animal Production, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria.
Department of Theriogenology and Production, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.
Theriogenology. 2016 Mar 15;85(5):862-869. doi: 10.1016/j.theriogenology.2015.10.034. Epub 2015 Nov 3.
Twenty pregnant Yankasa ewes were assigned to three groups to determine the effect of Trypanosoma evansi infection on pregnancy. Groups A and B comprising seven ewes each were infected with approximately 1.0 × 10(6) cells of T evansi per ewe through venepuncture at the second and third trimesters of pregnancy, respectively. Group C comprising six ewes served as uninfected control. There was slight pyrexia in the infected groups (groups A and B) but was absent in group C. The mean body weight, glucose concentration, and packed cell volume of ewes in group A were not significantly different from those in group C throughout the study. There was also no significant difference in mean glucose concentration between groups B and C. However, in group B, mean body weight was significantly (P < 0.05) lower compared to group C at week 2 and from week 4 post infection (pi) till the end of the study; the packed cell volume also significantly (P < 0.05) decreased but at weeks 4 and 6 pi. The mean plasma protein of ewes in group A was significantly (P < 0.05) increased compared to those of group C at weeks 7, 11 pi and thereafter till the end of the study. On the contrary, the plasma protein of ewes in group B decreased significantly (P < 0.05) compared to those in group C at weeks 2 and 6 pi. There were no reproductive losses throughout the study. This was characterized by insignificant differences in the gestation length between ewes in the infected groups (groups A and B) compared with those in group C. However, there were significant (P < 0.05) decreases in lamb birth weights of ewes in group B compared with ewes in groups A and C. Mice inoculation with blood from infected ewes postpartum was parasitemic 18 to 25 days pi, for ewes in group B, whereas none of the mice in groups A and C were parasitemic. Lambs born from the infected groups (groups A and B) were also aparasitemic for 40 days postpartum. It was therefore concluded that the T evansi isolate used caused mild trypanosomosis when infected at third trimester, whereas ewes infected at second trimester were resistant.
将20只怀孕的扬卡萨母羊分为三组，以确定伊氏锥虫感染对妊娠的影响。A组和B组每组有7只母羊，分别在妊娠中期和晚期通过静脉穿刺，每只母羊感染约1.0×10⁶个伊氏锥虫细胞。C组有6只母羊作为未感染对照。感染组（A组和B组）有轻微发热，而C组没有。在整个研究过程中，A组母羊的平均体重、血糖浓度和红细胞压积与C组没有显著差异。B组和C组的平均血糖浓度也没有显著差异。然而，在B组中，与C组相比，在感染后第2周以及从感染后第4周直到研究结束时，平均体重显著降低（P<0.05）；红细胞压积也显著降低（P<0.05），但在感染后第4周和第6周。在感染后第7周、第11周及之后直到研究结束时，A组母羊的平均血浆蛋白与C组相比显著升高（P<0.05）。相反，在感染后第2周和第6周，B组母羊的血浆蛋白与C组相比显著降低（P<0.05）。在整个研究过程中没有繁殖损失。其特征是感染组（A组和B组）母羊的妊娠期与C组相比差异不显著。然而，与A组和C组的母羊相比，B组母羊所产羔羊的出生体重显著降低（P<0.05）。产后用感染母羊的血液接种小鼠，对于B组母羊，感染后18至25天出现寄生虫血症，而A组和C组的小鼠均未出现寄生虫血症。感染组（A组和B组）出生的羔羊在产后40天也未出现寄生虫血症。因此得出结论，所使用的伊氏锥虫分离株在妊娠晚期感染时会引起轻度锥虫病，而在妊娠中期感染的母羊具有抗性。
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