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The Emerging Role of ABL Kinases in Solid Tumors.

作者信息

Wang Jun, Pendergast Ann Marie

机构信息

Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC 27710 USA.

出版信息

Trends Cancer. 2015 Oct 1;1(2):110-123. doi: 10.1016/j.trecan.2015.07.004.

DOI:10.1016/j.trecan.2015.07.004
PMID:26645050
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4669955/
Abstract

The Abelson (ABL) tyrosine kinases were identified as drivers of leukemia in mice and humans. Emerging data has shown a role for the ABL family kinases, ABL1 and ABL2, in the progression of several solid tumors. This review will focus on recent reports of the involvement of the ABL kinases in tumor progression using mouse models as well as recent data generated from genomic and proteomic studies linking enhanced expression and hyper-activation of the ABL kinases to some human cancers. Preclinical studies on small molecule inhibitors of the ABL kinases suggest that their use may have beneficial effects for the treatment of selected solid tumors.

摘要

相似文献

[1]
The Emerging Role of ABL Kinases in Solid Tumors.

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Abl Kinases Regulate HGF/Met Signaling Required for Epithelial Cell Scattering, Tubulogenesis and Motility.

PLoS One. 2015-5-6

[2]
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Cell Rep. 2015-4-21

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