a Eye Hospital, University Medical Centre , Ljubljana , Slovenia.
b Clinic of Pulmonary Disease and Allergy , University Medical Centre , Ljubljana , Slovenia.
Ocul Immunol Inflamm. 2016 Dec;24(6):660-664. doi: 10.3109/09273948.2015.1063669. Epub 2015 Dec 8.
To investigate the prevalence of suggestive signs for ocular sarcoidosis proposed by the International Workshop on Ocular Sarcoidosis (IWOS) in patients with sarcoidosis-associated uveitis.
A retrospective study included 53 patients (77% female), with uveitis, who were seen in the period of 2010-2013 at the University Eye Hospital Ljubljana, Slovenia. All patients had confirmed pulmonary sarcoidosis based on clinical presentation, imaging and lung biopsy according to the ATS/ERS criteria. The presence of the seven clinical signs, suggested by the IWOS was determined in 47 patients with sufficient clinical data.
Patients commonly exhibited bilaterality (79%), keratic precipitates/iris nodules (49%), and multiple chorioretinal peripheral lesions (36%). Three or more signs were observed in 40% (19/47) of patients or 79% (11/14) of patients with primary ocular involvement.
Results add to the validation of IWOS criteria and emphasize the high percentage of at least three suggestive for ocular sarcoidosis in patients with primary ocular involvement.
探讨国际眼内结节病研讨会(IWOS)提出的疑似眼内结节病的临床特征在结节病相关性葡萄膜炎患者中的流行情况。
回顾性研究纳入了 2010 年至 2013 年期间在斯洛文尼亚卢布尔雅那大学眼科医院就诊的 53 名(77%为女性)患有葡萄膜炎且确诊为结节病的患者。所有患者均根据 ATS/ERS 标准,通过临床表现、影像学和肺活检确诊为肺结节病。在具有充足临床资料的 47 名患者中,确定了 IWOS 提出的 7 个临床特征的存在情况。
患者通常表现为双眼受累(79%)、角膜后沉积物/虹膜结节(49%)和多发性脉络膜视网膜周边病变(36%)。在 40%(19/47)的患者或在 79%(11/14)的原发性眼部受累患者中,观察到 3 个或更多的特征。
研究结果进一步验证了 IWOS 标准,强调了在原发性眼部受累患者中,至少有 3 个疑似眼内结节病的特征的比例较高。