勃起功能障碍与心脏代谢功能障碍之间联系的基础科学证据。
Basic Science Evidence for the Link Between Erectile Dysfunction and Cardiometabolic Dysfunction.
作者信息
Musicki Biljana, Bella Anthony J, Bivalacqua Trinity J, Davies Kelvin P, DiSanto Michael E, Gonzalez-Cadavid Nestor F, Hannan Johanna L, Kim Noel N, Podlasek Carol A, Wingard Christopher J, Burnett Arthur L
机构信息
The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Division of Urology, Department of Surgery and Department of Neuroscience, Ottawa Hospital Research Institute at the University of Ottawa, Ottawa, ON, Canada.
出版信息
J Sex Med. 2015 Dec;12(12):2233-55. doi: 10.1111/jsm.13069. Epub 2015 Dec 8.
INTRODUCTION
Although clinical evidence supports an association between cardiovascular/metabolic diseases (CVMD) and erectile dysfunction (ED), scientific evidence for this link is incompletely elucidated.
AIM
This study aims to provide scientific evidence for the link between CVMD and ED.
METHODS
In this White Paper, the Basic Science Committee of the Sexual Medicine Society of North America assessed the current literature on basic scientific support for a mechanistic link between ED and CVMD, and deficiencies in this regard with a critical assessment of current preclinical models of disease.
RESULTS
A link exists between ED and CVMD on several grounds: the endothelium (endothelium-derived nitric oxide and oxidative stress imbalance); smooth muscle (SM) (SM abundance and altered molecular regulation of SM contractility); autonomic innervation (autonomic neuropathy and decreased neuronal-derived nitric oxide); hormones (impaired testosterone release and actions); and metabolics (hyperlipidemia, advanced glycation end product formation).
CONCLUSION
Basic science evidence supports the link between ED and CVMD. The Committee also highlighted gaps in knowledge and provided recommendations for guiding further scientific study defining this risk relationship. This endeavor serves to develop novel strategic directions for therapeutic interventions.
引言
尽管临床证据支持心血管/代谢疾病（CVMD）与勃起功能障碍（ED）之间存在关联，但这种联系的科学证据尚未完全阐明。
目的
本研究旨在为CVMD与ED之间的联系提供科学证据。
方法
在本白皮书中，北美性医学协会基础科学委员会评估了当前关于ED与CVMD之间机制联系的基础科学支持的文献，以及通过对当前疾病临床前模型的批判性评估在这方面存在的不足。
结果
ED与CVMD之间在多个方面存在联系：内皮（内皮衍生的一氧化氮和氧化应激失衡）；平滑肌（SM）（SM丰度和SM收缩性分子调节改变）；自主神经支配（自主神经病变和神经元衍生的一氧化氮减少）；激素（睾酮释放和作用受损）；以及代谢（高脂血症、晚期糖基化终产物形成）。
结论
基础科学证据支持ED与CVMD之间的联系。委员会还强调了知识空白，并为指导进一步明确这种风险关系的科学研究提供了建议。这一努力有助于为治疗干预制定新的战略方向。
Zotero 插件