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原位肝移植术中因食管出血而行挽救性内镜检查。

Intraoperative salvage endoscopy performed during orthotopic liver transplantation due to esophageal bleeding.

作者信息

Kobryn Konrad, Kozieł Sławomir, Patkowski Waldemar, Grąt Michał, Wróblewski Tadeusz, Krawczyk Marek

机构信息

Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.

出版信息

Wideochir Inne Tech Maloinwazyjne. 2015 Sep;10(3):472-6. doi: 10.5114/wiitm.2015.54559. Epub 2015 Sep 28.

Abstract

INTRODUCTION

Liver transplantation (LTx) is a widely accepted method of treatment for end stage liver diseases. There are many reports on the management of gastrointestinal bleeding (GIB) after LTx, however the number of studies concerning salvage endoscopic procedures during LTx are scarce.

AIM

We present our material of intraoperative endoscopic procedures due to GIB during LTx.

MATERIAL AND METHODS

During this period there were 4 females and 1 male at the mean age of 52.2 (35-65) years who underwent LTx and 1 patient had Re-LTx. All patients were Child-Pugh group C and mean MELD score was 17.75. Esophageal and/or gastric varices were present before surgery in all patients but only 1 female patient didn't experience GIB prior to LTx. Variables such as operating time, cold ischemic time, blood loss, blood transfusion, PLT count, international normalized ratio, albumin levels were similar in all patients thus making it statistically insignificant as the cause of GIB.

RESULTS

In all cases a single IOE was necessary and bleeding from ruptured varices succumbed to endoscopic ligation. In 2 patients besides trials of ligating the varix, histoacryl was put in use which proved success. In both these last female patients the endoscopic physician had to insert a Danis stent. A follow up endoscopy was performed on the 7-10 POD.

CONCLUSIONS

Intra-operative endoscopy performed during LTx does not interrupt surgery. Performed as soon as possible results in less future endoscopic interventions due to GIB. Intraoperative endoscopy may be considered as a salvage procedure and should be performed in the shortest possible time.

摘要

引言

肝移植(LTx)是治疗终末期肝病广泛接受的方法。关于肝移植后胃肠道出血(GIB)管理有许多报道,然而关于肝移植期间挽救性内镜手术的研究数量稀少。

目的

我们展示肝移植期间因GIB进行术中内镜手术的资料。

材料与方法

在此期间,4名女性和1名男性接受了肝移植,平均年龄52.2(35 - 65)岁,1例患者接受再次肝移植。所有患者均为Child - Pugh C组,平均终末期肝病模型(MELD)评分17.75。所有患者术前均存在食管和/或胃静脉曲张,但只有1名女性患者在肝移植前未发生GIB。所有患者的手术时间、冷缺血时间、失血量、输血、血小板计数、国际标准化比值、白蛋白水平等变量相似,因此作为GIB的原因在统计学上无显著意义。

结果

所有病例均需单次术中内镜检查(IOE),破裂静脉曲张出血通过内镜结扎得以控制。2例患者除尝试结扎静脉曲张外,还使用了组织黏合剂,证明成功。在这最后两名女性患者中,内镜医师均不得不插入丹尼斯支架。术后第7 - 10天进行了随访内镜检查。

结论

肝移植期间进行的术中内镜检查不会中断手术。尽早进行可减少未来因GIB进行的内镜干预。术中内镜检查可被视为一种挽救性手术,应在尽可能短的时间内进行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d47/4653274/88d2ae3d1af2/WIITM-10-25866-g001.jpg

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