Gupta R L, Kaur I P, Gupta A K, Pathak D P, Juneja T R
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Toxicol Lett. 1989 Jul;48(1):75-81. doi: 10.1016/0378-4274(89)90188-4.
Among the different metabolites of o-toluidine only the nitroso and hydroxylamino derivatives were found to be very potent frameshift mutagens in the presence of the co-mutagen norharman and S9. In the absence of norharman and S9 they are only base pair mutagens. Norharman failed to evoke the mutagenicity of the non-carcinogenic m- and p-toluidine and their respective nitroso and hydroxylamino metabolites. This report highlights that norharman plays a role in the appearance of mutagenicity of certain carcinogenic amines and metabolites.
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