氢化铜催化的烯烃和炔烃的氢胺化反应
Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes.
作者信息
Pirnot Michael T, Wang Yi-Ming, Buchwald Stephen L
机构信息
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA).
出版信息
Angew Chem Int Ed Engl. 2016 Jan 4;55(1):48-57. doi: 10.1002/anie.201507594. Epub 2015 Dec 10.
Abstract
Over the past few years, CuH-catalyzed hydroamination has been discovered and developed as a robust and conceptually novel approach for the synthesis of enantioenriched secondary and tertiary amines. The success in this area of research was made possible through the large body of precedent in copper(I) hydride catalysis and the well-explored use of hydroxylamine esters as electrophilic amine sources in related copper-catalyzed processes. This Minireview details the background, advances, and mechanistic investigations in CuH-catalyzed hydroamination.
摘要
在过去几年中，氢化亚铜催化的氢胺化反应已被发现并发展成为一种用于合成对映体富集仲胺和叔胺的稳健且概念新颖的方法。该研究领域的成功得益于氢化亚铜催化方面的大量先例以及在相关铜催化过程中作为亲电胺源的羟胺酯的广泛应用。本综述详细介绍了氢化亚铜催化氢胺化反应的背景、进展和机理研究。
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