KPNA2过表达是结直肠癌患者预后和治疗敏感性的潜在标志物。
KPNA2 over-expression is a potential marker of prognosis and therapeutic sensitivity in colorectal cancer patients.
作者信息
Takada Takahiro, Tsutsumi Soichi, Takahashi Ryo, Ohsone Katsuya, Tatsuki Hironori, Suto Toshinaga, Kato Toshihide, Fujii Takaaki, Yokobori Takehiko, Kuwano Hiroyuki
机构信息
Department of General Surgical Science, Graduate School of Medicine, Gunma University, Showamachi, Maebashi, Japan.
Department of Molecular Pharmacology and Oncology, Graduate School of Medicine, Gunma University, Gunma, Japan.
出版信息
J Surg Oncol. 2016 Feb;113(2):213-7. doi: 10.1002/jso.24114. Epub 2015 Dec 10.
BACKGROUND
Karyopherin α 2 (KPNA2) is a member of the Karyopherin α family and has recently been reported to play an important role in tumor progression. The aim of the current study was to elucidate the clinicopathological significance of KPNA2 over-expression in colorectal cancer (CRC).
PATIENTS AND METHODS
KPNA2 expression was evaluated by immunohistochemistry in 122 surgically resected CRC and 13 biopsy specimens obtained at colonoscopy during screening for preoperative hyperthermochemoradiation therapy (HCRT). The association between KPNA2 expression and clinicopathological features and preoperative HCRT efficacy were examined.
RESULTS
The high and low KNPA2 expression groups were comprised of 91 (74.6%) and 31 CRC patients, respectively. A significant association was observed between high expression and lymphatic invasion (P = 0.0245). KPNA2 high expression group had decreased overall survival (P = 0.00374). Multivariate analysis demonstrated high KPNA2 expression was independently associated with poor prognosis. Histological examinations revealed 11 (84.6%) and 2 (15.4%) of cases were KPNA2 positive and negative, respectively. Pathological complete response (pCR) was observed in 9.1% of KPNA2-positive cases and 100% of KPNA2-negative cases.
CONCLUSION
High KPNA2 expression was found to be associated with poor prognosis and resistance to HCRT.
背景
核转运蛋白α2（KPNA2）是核转运蛋白α家族的成员，最近有报道称其在肿瘤进展中起重要作用。本研究的目的是阐明KPNA2在结直肠癌（CRC）中过表达的临床病理意义。
患者与方法
通过免疫组织化学评估122例手术切除的CRC以及13例在术前热化疗放疗（HCRT）筛查期间通过结肠镜检查获得的活检标本中KPNA2的表达。研究了KPNA2表达与临床病理特征及术前HCRT疗效之间的关联。
结果
高KPNA2表达组和低KPNA2表达组分别包括91例（74.6%）和31例CRC患者。高表达与淋巴浸润之间存在显著关联（P = 0.0245）。KPNA2高表达组的总生存期降低（P = 0.00374）。多变量分析表明，高KPNA2表达与预后不良独立相关。组织学检查显示，分别有11例（84.6%）和2例（15.4%）病例为KPNA2阳性和阴性。在KPNA2阳性病例中有9.1%观察到病理完全缓解（pCR），而在KPNA2阴性病例中为100%。
结论
发现高KPNA2表达与预后不良及对HCRT耐药相关。
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