Shi Qiang, Tian Chenglin, Huang Xusheng, Pu Chuanqiang
Department of Neurology, Hainan Branch of Chinese PLA General Hospital, Beijing, China.
Department of Neurology, Chinese PLA General Hospital, Beijing, China.
Ann Clin Lab Sci. 2015 Fall;45(6):623-6.
Carbohydrate antigen series biomarkers in cerebrospinal fluid (CSF) are important for the diagnosis of brain metastasis and meningeal carcinomatosis. Its relationship with CSF and serum in non-neoplastic diseases may be beneficial for earlier diagnosis and treatment.
161 pairs of CSF and serum samples were obtained and compared. The 97.5th percentile and maximum value of carbohydrate antigen series biomarkers were obtained.
The 97.5th percentile and maximum value of CSF CA125, CA15-3 and CA19-9 concentration for overall participants was 4.31 u/ml and 4.59 u/ml, 2.01 and 3.65 u/ml, 2.71 u/ml and 3.00 u/ml, respectively. Gender had no significant effect on these three CSF biomarkers. The concentration of these three biomarkers in CSF were all lower than the paired serum concentration. The ratio of CA125, CA15-3 and CA19-9 level (CSF / serum) were from 0.018 to 0.69, 0.038 to 0.893, 0.017 to1, respectively.
Evaluation of intrathecal tumor markers synthesis is a specific, sensitive, reliable, and reproducible diagnostic tool. The values determined in this study of CSF carbohydrate antigen series biomarkers are significantly lower than what is usually used in clinical practice.
脑脊液（CSF）中的糖类抗原系列生物标志物对脑转移瘤和脑膜癌病的诊断很重要。其在非肿瘤性疾病中与脑脊液和血清的关系可能有助于早期诊断和治疗。
获取并比较了161对脑脊液和血清样本。得出糖类抗原系列生物标志物的第97.5百分位数和最大值。
总体参与者脑脊液CA125、CA15 - 3和CA19 - 9浓度的第97.5百分位数和最大值分别为4.31 u/ml和4.59 u/ml、2.01和3.65 u/ml、2.71 u/ml和3.00 u/ml。性别对这三种脑脊液生物标志物无显著影响。这三种生物标志物在脑脊液中的浓度均低于配对血清浓度。CA125、CA15 - 3和CA19 - 9水平（脑脊液/血清）的比值分别为0.018至0.69、0.038至0.893、0.017至1。
鞘内肿瘤标志物合成的评估是一种特异、敏感、可靠且可重复的诊断工具。本研究中确定的脑脊液糖类抗原系列生物标志物的值显著低于临床实践中通常使用的值。
Zotero 插件